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Centrosomal Protein 55kDa (CEP55)

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CT111; URCC6; C10orf3; Cancer/Testis Antigen 111; Up-regulated in colon cancer 6

Centrosomal Protein 55kDa (CEP55)
CCC F267
HGNC 1161
MGI 1921357
PubMed 20176808
RGD 1305340
UniProt Q53EZ4
Wiki CEP55
CEP55 expression in testis and thymus, lower expression in small intestine, colon, and ovary, and little to no expression in other tissues examined. Fluorescence-tagged CEP55 localized to centrioles and, primarily, to the pericentriolar material. Further analysis indicated that CEP55 localized to the mother centriole in interphase cells and was recruited to the midbody during cytokinesis. Phosphatase treatment indicated that the doublet was phosphorylated.After long exposure time, CEP55 was expressed in all tissues examined. Immunohistochemical analysis detected endogenous Cep55 in Chinese hamster ovary cells at the centrosome as 1 or 2 dots during mitosis. Cep55 appeared at the cleavage furrow in late anaphase and concentrated at the center of the midbody during cytokinesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF267Hu01 Recombinant Centrosomal Protein 55kDa (CEP55) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 55kDa (CEP55) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 55kDa (CEP55) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 55kDa (CEP55) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 55kDa (CEP55) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF267Mu01 Recombinant Centrosomal Protein 55kDa (CEP55) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Centrosomal Protein 55kDa (CEP55) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Centrosomal Protein 55kDa (CEP55) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Centrosomal Protein 55kDa (CEP55) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 55kDa (CEP55) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF267Ra01 Recombinant Centrosomal Protein 55kDa (CEP55) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF267Ra01 Polyclonal Antibody to Centrosomal Protein 55kDa (CEP55) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Centrosomal Protein 55kDa (CEP55) CLIA Kit Customized Service Offer
n/a ELISA Kit for Centrosomal Protein 55kDa (CEP55) ELISA Kit Customized Service Offer
  1. "The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody."Genomics 87:243-253(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis."Dev. Cell 9:477-488(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery."Science 316:1908-1912(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55."Science 322:576-580(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]