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Bcl2 Associated Athanogene 1 (BAG1)

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HAP; BAG family molecular chaperone regulator 1

Bcl2 Associated Athanogene 1 (BAG1)
CCC F228
HGNC 937
MGI 108047
PubMed 8812483
RGD 1305203
UniProt Q99933
Wiki BAG1
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death.BCL2 Associated Athanogene 1 binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.
BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF228Hu01 Recombinant Bcl2 Associated Athanogene 1 (BAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF228Hu01 Polyclonal Antibody to Bcl2 Associated Athanogene 1 (BAG1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bcl2 Associated Athanogene 1 (BAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Athanogene 1 (BAG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF228Mu01 Recombinant Bcl2 Associated Athanogene 1 (BAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Bcl2 Associated Athanogene 1 (BAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bcl2 Associated Athanogene 1 (BAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bcl2 Associated Athanogene 1 (BAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Athanogene 1 (BAG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF228Ra01 Recombinant Bcl2 Associated Athanogene 1 (BAG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF228Ra01 Polyclonal Antibody to Bcl2 Associated Athanogene 1 (BAG1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bcl2 Associated Athanogene 1 (BAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated Athanogene 1 (BAG1) ELISA Kit Customized Service Offer
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  3. "Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity."Int. J. Cancer 117:896-904(2005) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation."Biochem. J. 328:807-813(1997) [PubMed] [Europe PMC] [Abstract]
  7. "BAG-1 modulates the chaperone activity of Hsp70/Hsc70."EMBO J. 16:4887-4896(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines."Cancer Res. 58:3116-3131(1998) [PubMed] [Europe PMC] [Abstract]
  9. "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1."EMBO J. 17:2736-2747(1998) [PubMed] [Europe PMC] [Abstract]
  10. "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
  11. "A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity."J. Cell Biol. 146:929-940(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions."Mol. Cell. Biol. 23:3477-3486(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors."Science 291:1553-1557(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the ubiquitin domain of Bcl-2 binding athanogene-1."Submitted (AUG-2005) to the PDB data bank