Fucosyltransferase 1 (FUT1)

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H; HH; HSC; Galactoside 2-Alpha-L-Fucosyltransferase,H Blood Group; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; Blood group H alpha 2-fucosyltransferase

Fucosyltransferase 1 (FUT1)
FUT1 is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. An analysis of the results of ABO typing at transfusion centers on the island confirmed their prediction; 42 persons were found to be lacking H-antigen on red cells with anti-H in their serum. A, B, and AB Bombay subjects had small but detectable amounts of A and/or B antigens on erythrocytes. All H-deficient persons were nonsecretors, and one-third were Lewis negative. Of 108 unaffected persons in 14 Bombay pedigrees, 53 (49%) were se/se, suggesting that the Bombay probands have an se/se genotype.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF193Hu01 Recombinant Fucosyltransferase 1 (FUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fucosyltransferase 1 (FUT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fucosyltransferase 1 (FUT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fucosyltransferase 1 (FUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fucosyltransferase 1 (FUT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF193Mu01 Recombinant Fucosyltransferase 1 (FUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF193Mu01 Polyclonal Antibody to Fucosyltransferase 1 (FUT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fucosyltransferase 1 (FUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fucosyltransferase 1 (FUT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF193Ra01 Recombinant Fucosyltransferase 1 (FUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Fucosyltransferase 1 (FUT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fucosyltransferase 1 (FUT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fucosyltransferase 1 (FUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fucosyltransferase 1 (FUT1) ELISA Kit Customized Service Offer
  1. "Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen."Proc. Natl. Acad. Sci. U.S.A. 87:6674-6678(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles."Transfusion 37:284-290(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals which inactivate H enzyme."Blood 90:839-849(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals."Proc. Natl. Acad. Sci. U.S.A. 91:5843-5847(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system."Biochem. Biophys. Res. Commun. 238:21-25(1997) [PubMed] [Europe PMC] [Abstract]