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Sirtuin 6 (SIRT6)

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SIR2L6; Silent Mating Type Information Regulation 2 Homolog 6; Mono-ADP-Ribosyltransferase Sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6

Sirtuin 6 (SIRT6)
CCC E916
HGNC 14934
MGI 1354161
PubMed 22367546
RGD 1305216
UniProt Q8N6T7
Wiki SIRT6
SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.Sirtuins can be divided into 4 main classes in eukaryotes based on amino acid sequence motifs, with yeast Sir2 belonging to class Ia. The deduced 355-amino acid SIRT6 protein is a class IV sirtuin, a class not present in prokaryotes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE916Hu01 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE916Hu02 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE916Hu01 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
LAE916Hu71 Biotin-Linked Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC.
LAE916Hu81 FITC-Linked Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
MAE916Hu21 Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
Assay Kits SEE916Hu ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE916Mu01 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE916Mu02 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE916Mu01 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
LAE916Mu71 Biotin-Linked Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC.
PAE916Mu02 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
Assay Kits SEE916Mu ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE916Ra01 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE916Ra01 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
LAE916Ra71 Biotin-Linked Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Sirtuin 6 (SIRT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sirtuin 6 (SIRT6) ELISA Kit Customized Service Offer
  1. "Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins."Biochem. Biophys. Res. Commun. 273:793-798(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
  6. "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin."Nature 452:492-496(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span."Cell 136:62-74(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6."Cell Cycle 8:2664-2666(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Human SIRT6 promotes DNA end resection through CtIP deacetylation."Science 329:1348-1353(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structure and biochemical functions of SIRT6."J. Biol. Chem. 286:14575-14587(2011) [PubMed] [Europe PMC] [Abstract]