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Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A)

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NMDAR2A; NR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A)
CCC E806
HGNC 4585
MGI 95820
PubMed 23933819
RGD 2737
UniProt Q12879
Wiki GRIN2A
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.
NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).Rat counterparts of the mouse E1, E2, E3, E4, and zeta-1 (Z1; GRIN1) subunits were also isolated and designated as Nr2a, Nr2b, Nr2c, Nr2d, and Nmdar1, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE806Hu01 Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE806Hu01 Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) WB; IHC; ICC; IP.
MAE806Hu21 Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) WB; IHC; ICC; IP.
Assay Kits SEE806Hu ELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Enzyme-linked immunosorbent assay for Antigen Detection.
AEE806Hu ELISA Kit for Anti-Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A Antibody (Anti-GRIN2A) Enzyme-linked immunosorbent assay for Antibody Detection.
SCE806Hu CLIA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE806Mu01 Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Positive Control; Immunogen; SDS-PAGE; WB.
RPE806Mu02 Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE806Mu01 Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) WB; IHC; ICC; IP.
PAE806Mu02 Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) WB; IHC; ICC; IP.
Assay Kits SEE806Mu ELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE806Ra01 Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Polyclonal Antibody Customized Service Offer
Assay Kits SEE806Ra ELISA Kit for Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein."Biochim. Biophys. Acta 1223:155-159(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes." Nat. Genet. 42:1021-1026(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Exome sequencing identifies GRIN2A as frequently mutated in melanoma."Nat. Genet. 43:442-446(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  8. "GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction." Nat. Genet. 45:1061-1066(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes." Nat. Genet. 45:1067-1072(2013) [PubMed] [Europe PMC] [Abstract]
  10. "GRIN2A mutations cause epilepsy-aphasia spectrum disorders." Nat. Genet. 45:1073-1076(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Evidence that GRIN2A mutations in melanoma correlate with decreased survival."Front. Oncol. 3:333-333(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Whole-exome sequencing in an individual with severe global developmental delay and intractable epilepsy identifies a novel, de novo GRIN2A mutation."Epilepsia 55:E75-E79(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy."Nat. Commun. 5:3251-3251(2014) [PubMed] [Europe PMC] [Abstract]