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Pannexin 1 (PANX1)

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MRS1; PX1; Innexin

Pannexin 1 (PANX1)
CCC E788
HGNC 8599
MGI 1860055
PubMed 18596211
RGD 735204
UniProt Q96RD7
Wiki PANX1
Pannexin 1 belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. The deduced 48-kD protein contains 4 transmembrane domains and cytoplasmic N and C termini. Northern blot analysis detected Panx1 expression in rat eye, thyroid, prostate, kidney, liver, and central nervous system. In situ hybridization showed Pnx1 expression in several brain regions, including cortex, striatum, olfactory bulb, hippocampus, thalamus, and cerebellum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE788Hu01 Recombinant Pannexin 1 (PANX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE788Hu01 Polyclonal Antibody to Pannexin 1 (PANX1) WB; IHC; ICC; IP.
Assay Kits SEE788Hu ELISA Kit for Pannexin 1 (PANX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE788Mu01 Recombinant Pannexin 1 (PANX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Pannexin 1 (PANX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pannexin 1 (PANX1) Polyclonal Antibody Customized Service Offer
Assay Kits SEE788Mu ELISA Kit for Pannexin 1 (PANX1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE788Ra01 Recombinant Pannexin 1 (PANX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE788Ra01 Polyclonal Antibody to Pannexin 1 (PANX1) WB; IHC; ICC; IP.
Assay Kits SEE788Ra ELISA Kit for Pannexin 1 (PANX1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins."Genomics 83:706-716(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Functional implications of calcium permeability of the channel formed by pannexin 1."J. Cell Biol. 174:535-546(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane."J. Biol. Chem. 282:31733-31743(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity."J. Biol. Chem. 285:38444-38452(2010) [PubMed] [Europe PMC] [Abstract]