![Karyopherin Alpha 5 (KPNa5)](/upload/item/img/Karyopherin-Alpha-5-(KPNa5)-94751.jpg)
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs).
KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. Of the known human importin-alphas, KPNA5 shares the highest sequence identity with SRP1 (KPNA1). Northern blot analysis detected a 2.4-kb KPNA5 transcript only in testis.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE751Hu01 | Recombinant Karyopherin Alpha 5 (KPNa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Karyopherin Alpha 5 (KPNa5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Karyopherin Alpha 5 (KPNa5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Karyopherin Alpha 5 (KPNa5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Karyopherin Alpha 5 (KPNa5) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE751Mu01 | Recombinant Karyopherin Alpha 5 (KPNa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Karyopherin Alpha 5 (KPNa5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Karyopherin Alpha 5 (KPNa5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Karyopherin Alpha 5 (KPNa5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Karyopherin Alpha 5 (KPNa5) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPE751Ra01 | Recombinant Karyopherin Alpha 5 (KPNa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Karyopherin Alpha 5 (KPNa5) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Karyopherin Alpha 5 (KPNa5) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Karyopherin Alpha 5 (KPNa5) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Karyopherin Alpha 5 (KPNa5) | ELISA Kit Customized Service Offer |
- "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family."FEBS Lett. 417:104-108(1997) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein."J. Biol. Chem. 278:28193-28200(2003) [PubMed] [Europe PMC] [Abstract]
- "A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway."J. Virol. 77:3734-3748(2003) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]