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Insulin Receptor Substrate 2 (IRS2)

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Insulin Receptor Substrate 2 (IRS2)
CCC D880
HGNC 6126
MGI 109334
PubMed 11994408
RGD 69316
UniProt Q9Y4H2
Wiki IRS2
Insulin receptor substrate 2 is a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.. Mice lacking IRS2 have a diabetic phenotype as well as a 40% reduction in brain mass.Insulin receptor substrate-2 (IRS-2) is a multisite docking protein implicated in mitogenic signaling after activation of the insulin and insulin-like growth factor (IGF)-I receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD880Hu01 Recombinant Insulin Receptor Substrate 2 (IRS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD880Hu01 Polyclonal Antibody to Insulin Receptor Substrate 2 (IRS2) WB,IHC,ICC/IF
Assay Kits SED880Hu ELISA Kit for Insulin Receptor Substrate 2 (IRS2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD880Mu01 Recombinant Insulin Receptor Substrate 2 (IRS2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD880Mu02 Recombinant Insulin Receptor Substrate 2 (IRS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD880Mu01 Polyclonal Antibody to Insulin Receptor Substrate 2 (IRS2) WB; IHC; ICC; IP.
PAD880Mu02 Polyclonal Antibody to Insulin Receptor Substrate 2 (IRS2) WB; IHC; ICC; IP.
Assay Kits SED880Mu ELISA Kit for Insulin Receptor Substrate 2 (IRS2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD880Ra01 Recombinant Insulin Receptor Substrate 2 (IRS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD880Ra01 Polyclonal Antibody to Insulin Receptor Substrate 2 (IRS2) WB; IHC; ICC; IP.
MAD880Ra21 Monoclonal Antibody to Insulin Receptor Substrate 2 (IRS2) WB; IHC; ICC; IP.
Assay Kits SED880Ra ELISA Kit for Insulin Receptor Substrate 2 (IRS2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain."J. Biol. Chem. 272:25267-25274(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene."Mol. Endocrinol. 13:485-494(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation."Hum. Genet. 113:34-43(2003) [PubMed] [Europe PMC] [Abstract]