Branched Chain Aminotransferase 2, Mitochondrial (BCAT2)

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BCAM; BCT2; PP18; BCATM; ECA40; Placental protein 18; Branched-chain-amino-acid aminotransferase, mitochondrial

Branched Chain Aminotransferase 2, Mitochondrial (BCAT2)
BCAT2 encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene.Eden et al. (1996) characterized the BCAT2 gene in human and yeast and demonstrated that the yeast homologs of Bcat1and Bcat2 code for cytosolic and mitochondrial enzymes, respectively.By study of somatic cell hybrids, Naylor and Shows ssigned the gene for BCT2 to chromosome 19.Bassett et al. (1997) mapped the mouse Bcat2 gene to chromosome 7 as part of the XREF project. On the basis of the conserved synteny between mouse and human chromosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD859Hu01 Recombinant Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD859Hu01 Polyclonal Antibody to Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD859Mu01 Recombinant Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD859Mu01 Polyclonal Antibody to Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD859Ra01 Recombinant Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD859Ra01 Polyclonal Antibody to Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Branched Chain Aminotransferase 2, Mitochondrial (BCAT2) ELISA Kit Customized Service Offer
  1. "Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm)."Biochim. Biophys. Acta 1339:9-13(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of placental tissue protein 18 (PP18a)/human mitochondrial branched-chain aminotransferase (BCATm) and its novel alternatively spliced PP18b variant."Placenta 22:235-243(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases."J. Biol. Chem. 271:20242-20245(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The structure of human mitochondrial branched-chain aminotransferase."Acta Crystallogr. D 57:506-515(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms."Biochemistry 41:11592-11601(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin."J. Biol. Chem. 280:37246-37256(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis."J. Biol. Chem. 281:39660-39671(2006) [PubMed] [Europe PMC] [Abstract]