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Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI)

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ACBD2; DRS1; HCA88; ECI2; Diazepam-binding inhibitor-related protein 1; Acyl-Coenzyme A Binding Domain Containing 2; Hepatocellular Carcinoma-Associated Antigen 88

Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI)
CCC D694
HGNC 14601
MGI 1346064
PubMed 10419495
RGD 1359427
UniProt O75521
PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.Human PECI contains 2 putative start codons, while mouse Peci contains only the second start codon. Both contain a C-terminal peroxisomal targeting signal. Northern blot analysis detected a 1.5-kb transcript in all human tissues examined. Highest expression was detected in heart, skeletal muscle, and liver. Western blot analysis of fibroblasts showed that endogenous PECI migrated with an apparent molecular mass of 39 kD. PECI partitioned with peroxisomal markers following fractionation of hepatocellular carcinoma cells, and immunofluorescence microscopy of differentially permeabilized fibroblasts indicated that PECI is a peroxisomal matrix protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD694Hu01 Recombinant Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD694Hu01 Polyclonal Antibody to Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD694Mu01 Recombinant Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD694Mu01 Polyclonal Antibody to Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD694Ra01 Recombinant Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD694Ra01 Polyclonal Antibody to Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal D3, D2-Enoyl Coenzyme A Isomerase (PECI) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor."Biochim. Biophys. Acta 1454:126-131(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of PECI, a novel monofunctional D3,D2-enoyl-CoA isomerase of mammalian peroxisomes."J. Biol. Chem. 274:21797-21803(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing."EMBO Rep. 1:287-292(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells."Blood 104:2425-2431(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of RSGI RUH-045, a human acyl-CoA binding protein."Submitted (NOV-2005) to the PDB data bank
  15. "The crystal structure of human peroxisomal delta3, delta2 enoyl-CoA isomerase (pECI)."Submitted (FEB-2009) to the PDB data bank