Heat Shock Protein 90kDa Alpha A1 (HSP90aA1)

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HSP86; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp89; Hsp90; LAP2; Lipopolysaccharide-associated protein 2; Renal carcinoma antigen NY-REN-38

Heat Shock Protein 90kDa Alpha A1 (HSP90aA1)
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1) and mitochondria (TRAP1).In humans, 2 distinct HSP90 cDNA clones were identified that hybrid-select different mRNA transcripts encoding 2 members of the HSP90 family. These were called HSP89-alpha and HSP89-beta

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD523Hu01 Recombinant Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD523Hu01 Polyclonal Antibody to Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) WB; IHC; ICC; IP.
LAD523Hu71 Biotin-Linked Polyclonal Antibody to Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) WB; IHC; ICC.
LAD523Hu81 FITC-Linked Polyclonal Antibody to Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) WB; IHC; ICC; IF.
Assay Kits SED523Mi ELISA Kit for Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Recombinant Protein Customized Service Offer
Antibodies PAD523Mu01 Polyclonal Antibody to Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) WB; IHC; ICC; IP.
Assay Kits SED523Mi ELISA Kit for Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Polyclonal Antibody Customized Service Offer
Assay Kits SED523Mi ELISA Kit for Heat Shock Protein 90kDa Alpha A1 (HSP90aA1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes."Nucleic Acids Res. 17:7108-7108(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of cDNA encoding a human heat-shock protein whose expression is induced by adenovirus type 12 E1A in HeLa cells."Agric. Biol. Chem. 54:3163-3170(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein."Mol. Cell. Biol. 9:2615-2626(1989) [PubMed] [Europe PMC] [Abstract]
  4. "The HSP90 family of genes in the human genome: insights into their divergence and evolution."Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens."Gene 74:491-501(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene."Gene 83:105-115(1989) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (DEC-2008) to UniProtKB
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II."J. Biol. Chem. 264:2431-2437(1989) [PubMed] [Europe PMC] [Abstract]
  12. "S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities."Proc. Natl. Acad. Sci. U.S.A. 102:8525-8530(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues."J. Biol. Chem. 264:17275-17280(1989) [PubMed] [Europe PMC] [Abstract]
  14. "The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo."Mol. Cell. Biol. 14:1459-1464(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Mechanism of dimer formation of the 90-kDa heat-shock protein."Eur. J. Biochem. 233:1-8(1995) [PubMed] [Europe PMC] [Abstract]
  16. "Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin."J. Biol. Chem. 272:16224-16230(1997) [PubMed] [Europe PMC] [Abstract]
  17. "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90."J. Biol. Chem. 273:18007-18010(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase."J. Biol. Chem. 276:15571-15574(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex."J. Biol. Chem. 276:45791-45799(2001) [PubMed] [Europe PMC] [Abstract]
  21. "A CD14-independent LPS receptor cluster."Nat. Immunol. 2:338-345(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system."EMBO J. 22:3613-3623(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone."J. Biol. Chem. 278:17228-17235(2003) [PubMed] [Europe PMC] [Abstract]
  24. "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells."Nat. Cell Biol. 6:731-740(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole."Biochem. J. 385:45-56(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Molecular basis for TPR domain-mediated regulation of protein phosphatase 5."EMBO J. 24:1-10(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Phosphoproteomic analysis of the human pituitary."Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90."Structure 14:415-426(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  31. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  32. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  33. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  36. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  38. "A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein."Mol. Cell. Proteomics 9:255-270(2010) [PubMed] [Europe PMC] [Abstract]
  39. "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."Biochem. Biophys. Res. Commun. 336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
  40. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  41. "Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling."Proc. Natl. Acad. Sci. U.S.A. 103:15552-15557(2006) [PubMed] [Europe PMC] [Abstract]
  42. "The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis."Development 135:1147-1156(2008) [PubMed] [Europe PMC] [Abstract]
  43. "Hsp90 is regulated by a switch point in the C-terminal domain."EMBO Rep. 10:1147-1153(2009) [PubMed] [Europe PMC] [Abstract]
  44. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  46. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  47. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  48. "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling."Oncotarget 5:1666-1682(2014) [PubMed] [Europe PMC] [Abstract]
  49. "Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent."Cell 89:239-250(1997) [PubMed] [Europe PMC] [Abstract]
  50. "In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis."J. Cell Biol. 143:901-910(1998) [PubMed] [Europe PMC] [Abstract]
  51. "Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex."Mol. Cell 20:525-538(2005) [PubMed] [Europe PMC] [Abstract]