5-Carboxamidotryptamine (5-CT)

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-hydroxytryptamine(5-HT) is an important neurotransmitter made by neurons in the central nervous system. These functions are mediated by a large number of receptors. After it is released by a neuron, 5-HT activates receptors located on nearby neurons.

In isolated dog coronary arteries, serotonin (5-HT) produced a contraction, whereas 5-carboxamidotryptamine (5-CT), a serotonergic 5-HT1-like receptor agonist, mainly relaxed the arteries, and the contraction, if any, was slight. Human and Japanese monkey coronary artery strips responded to these amines only with contractions, the magnitude being markedly greater than that of serotonin-induced contractions in the dog arteries.