Lahn and Page (1997) isolated testis cDNAs encoding TB4Y, a Y-linked TB4X homolog. They identified TB4Y as 1 of 5 NRY genes that were expressed in many tissues and have homologs on the X chromosome that escape X inactivation.
The antigen, an 11-mer peptide (EVLLRPGLHFR), was encoded by a polymorphic region 405 bp upstream of the initiation codon of TMSB4Y. CTL precursor frequency analysis showed that approximately 25% of the total donor CTL responses in the patient 50 days after transplant were directed at this epitope, and the precursor was detectable almost 2 years after transplant. RT-PCR analysis detected wide expression of TMSB4Y mRNA in normal tissues, including hematopoietic cells, and TMSB4Y was also expressed in some leukemic cells.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD240Hu01 | Recombinant Thymosin Beta 4, Y-Chromosomal (Tb4Y) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD240Hu01 | Polyclonal Antibody to Thymosin Beta 4, Y-Chromosomal (Tb4Y) | WB; IHC; ICC; IP. |
MAD240Hu21 | Monoclonal Antibody to Thymosin Beta 4, Y-Chromosomal (Tb4Y) | WB; IHC; ICC; IP. | |
Assay Kits | CED240Hu | ELISA Kit for Thymosin Beta 4, Y-Chromosomal (Tb4Y) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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