≡

T-Cell Surface Glycoprotein CD3 Epsilon (CD3e)

[Edit]

T3E; TCRE; CD3-E Molecule,Epsilon(CD3-TCR Complex); T-cell surface antigen T3/Leu-4 epsilon chain

T-Cell Surface Glycoprotein CD3 Epsilon (CD3e)
CCC D117
HGNC 1674
MGI 88332
PubMed 9885898
RGD 1309222
UniProt P07766
Wiki CD3E
CD3e molecule, epsilon is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.
Defects in this gene cause severe immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD117Hu01 Recombinant T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Positive Control; Immunogen; SDS-PAGE; WB.
EPD117Hu61 Eukaryotic T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Positive Control; Immunogen; SDS-PAGE; WB.
EPD117Hu62 Eukaryotic T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Positive Control; Immunogen; SDS-PAGE; WB.
APD117Hu61 Active T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Cell culture; Activity Assays.
APD117Hu62 Active T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Cell culture; Activity Assays.
Antibodies PAD117Hu01 Polyclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
MAD117Hu21 Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC
MAD117Hu22 Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
MAD117Hu23 Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
MAD117Hu24 Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
MAD117Hu25 Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
MAD117Hu27 Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD117Mu01 Recombinant T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies LAD117Mu51 APC-Linked Polyclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IF.
PAD117Mu01 Polyclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD117Ra01 Recombinant T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) ELISA Kit Customized Service Offer
  1. "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex."Nature 321:431-434(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter."Proc. Natl. Acad. Sci. U.S.A. 85:8156-8160(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency."Nat. Genet. 3:77-81(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3."J. Clin. Invest. 114:1512-1517(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide."J. Mol. Biol. 281:523-537(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3."Proc. Natl. Acad. Sci. U.S.A. 101:7675-7680(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment."Proc. Natl. Acad. Sci. U.S.A. 101:16268-16273(2004) [PubMed] [Europe PMC] [Abstract]