Menatetrenoneis a menaquinone compound used as a hemostatic agent and as adjunctive therapy for the pain of osteoporosis. It is also known as Vitamin K2, but there are several menaquinone forms that are also referred to as Vitamin K2. Menatetrenone is just one of nine forms. Vitamin K2 is normally produced by bacteria in the large intestine, and dietary deficiency is extremely rare unless the intestines are heavily damaged, are unable to absorb the molecule, or are subject to decreased production by normal flora, as seen in broad spectrum antibiotic use. MK4 is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls. While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK4, studies demonstrate the conversion is not dependent on gut bacteria, occurring in germ-free rats and in parenterally-administered K1 in rats.
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