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Ferritin, Heavy Polypeptide (FTH)

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FTH1; FTHL6; PIG15; PLIF; Ferritin Heavy Chain; Apoferritin; Placenta Immunoregulatory Factor; Proliferation-Inducing Protein 15; Cell proliferation-inducing gene 15 protein

Ferritin, Heavy Polypeptide (FTH)
CCC D021
HGNC 3976
MGI 95588
PubMed 22212821
RGD 2635
UniProt P02794
Wiki FTH1

Ferritin heavy chain is a heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.The functionality of the gene was demonstrated by the fact that both transient transfectants and stable transformants of mouse fibroblasts actively transcribed human ferritin heavy-chain mRNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD021Hu01 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD021Hu01 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC/IF
MAD021Hu21 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC
MAD021Hu23 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
MAD021Hu22 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
MAD021Hu24 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
Assay Kits SED021Hu ELISA Kit for Ferritin, Heavy Polypeptide (FTH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD021Mu01 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
RPD021Mu02 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD021Mu01 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC
LAD021Mu71 Biotin-Linked Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC.
LAD021Mu81 FITC-Linked Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IF.
PAD021Mu02 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
MAD021Mu21 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
MAD021Mu27 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
MAD021Mu29 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB;ICC/IF
MAD021Mu22 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
MAD021Mu23 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
Assay Kits SED021Mu ELISA Kit for Ferritin, Heavy Polypeptide (FTH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD021Ra01 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD021Ra01 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
LAD021Ra71 Biotin-Linked Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC.
MAD021Ra21 Monoclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
Assay Kits SED021Ra ELISA Kit for Ferritin, Heavy Polypeptide (FTH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD021Po01 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD021Po01 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC/IF
Assay Kits n/a CLIA Kit for Ferritin, Heavy Polypeptide (FTH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferritin, Heavy Polypeptide (FTH) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD021Ov01 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD021Ov01 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
LAD021Ov71 Biotin-Linked Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC.
LAD021Ov81 FITC-Linked Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Ferritin, Heavy Polypeptide (FTH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferritin, Heavy Polypeptide (FTH) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD021Eq01 Recombinant Ferritin, Heavy Polypeptide (FTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD021Eq01 Polyclonal Antibody to Ferritin, Heavy Polypeptide (FTH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ferritin, Heavy Polypeptide (FTH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ferritin, Heavy Polypeptide (FTH) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family."EMBO J. 3:23-27(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones."J. Biol. Chem. 260:11755-11761(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro."Mol. Cell. Biol. 6:566-573(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of gene and pseudogenes of human apoferritin H."Nucleic Acids Res. 14:721-736(1986) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene."Proc. Natl. Acad. Sci. U.S.A. 83:7226-7230(1986) [PubMed] [Europe PMC] [Abstract]
  6. "Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain."Gene 126:275-278(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation and characterization of a cDNA clone for human ferritin heavy chain."Proc. Natl. Acad. Sci. U.S.A. 81:4751-4755(1984) [PubMed] [Europe PMC] [Abstract]
  10. "A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload."Am. J. Hum. Genet. 69:191-197(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts."Nature 349:541-544(1991) [PubMed] [Europe PMC] [Abstract]
  20. "Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution."J. Mol. Biol. 268:424-448(1997) [PubMed] [Europe PMC] [Abstract]