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Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6)

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CD66c; NCA; CD66-C; CEAL; Non-Specific Cross Reacting Antigen; Normal cross-reacting antigen

Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6)
CCC C980
HGNC 1818
PubMed 19334050
UniProt P40199
Wiki CEACAM6
CEACAM6 acted as a receptor for AIEC adhesion and was upregulated in the ileal mucosa of CD patients compared to colonic mucosa or to controls. In vitro studies showed increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC. Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma.
CEACAM6 blocked adenovirus trafficking to the nucleus through the SRC pathway, interfering with cancer cell cytoskeleton and reducing adenoviral infection. Knockdown of CEACAM6 with small interfering RNA significantly increased adenovirus replication and antitumor efficacy of oncolytic adenovirus in a mouse xenograft tumor model.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC980Hu01 Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) Positive Control; Immunogen; SDS-PAGE; WB.
RPC980Hu03 Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) Positive Control; Immunogen; SDS-PAGE; WB.
RPC980Hu02 Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC980Hu01 Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) WB; IHC; ICC; IP.
MAC980Hu22 Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) WB; IHC; ICC; IP.
PAC980Hu02 Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) WB; IHC; ICC; IP.
Assay Kits SEC980Hu ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence."Biochem. Biophys. Res. Commun. 150:89-96(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen."J. Biol. Chem. 263:3202-3207(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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