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Platelet Derived Growth Factor C (PDGFC)

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PDGF-C; SCDGF; VEGF-E; Fallotein; Spinal cord-derived growth factor; Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form

Platelet Derived Growth Factor C (PDGFC)
CCC C920
HGNC 8801
MGI 1859631
PubMed 10806482
RGD 68410
UniProt Q9NRA1
Wiki PDGFC
Platelet-derived growth factor C is a member of the platelet-derived growth factor family. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC920Hu01 Recombinant Platelet Derived Growth Factor C (PDGFC) Positive Control; Immunogen; SDS-PAGE; WB.
APC920Hu01 Active Platelet Derived Growth Factor C (PDGFC) Cell culture; Activity Assays.
EPC920Hu61 Eukaryotic Platelet Derived Growth Factor C (PDGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC920Hu01 Polyclonal Antibody to Platelet Derived Growth Factor C (PDGFC) WB; IHC; ICC; IP.
MAC920Hu22 Monoclonal Antibody to Platelet Derived Growth Factor C (PDGFC) WB; IHC; ICC; IP.
Assay Kits SEC920Hu ELISA Kit for Platelet Derived Growth Factor C (PDGFC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC920Hu CLIA Kit for Platelet Derived Growth Factor C (PDGFC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC920Mu01 Recombinant Platelet Derived Growth Factor C (PDGFC) Positive Control; Immunogen; SDS-PAGE; WB.
RPC920Mu02 Recombinant Platelet Derived Growth Factor C (PDGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC920Mu01 Polyclonal Antibody to Platelet Derived Growth Factor C (PDGFC) WB; IHC; ICC; IP.
PAC920Mu02 Polyclonal Antibody to Platelet Derived Growth Factor C (PDGFC) WB; IHC; ICC; IP.
Assay Kits SEC920Mu ELISA Kit for Platelet Derived Growth Factor C (PDGFC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC920Mu CLIA Kit for Platelet Derived Growth Factor C (PDGFC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC920Ra01 Recombinant Platelet Derived Growth Factor C (PDGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC920Ra01 Polyclonal Antibody to Platelet Derived Growth Factor C (PDGFC) WB; IHC; ICC; IP.
MAC920Ra21 Monoclonal Antibody to Platelet Derived Growth Factor C (PDGFC) WB; IHC; ICC; IP.
Assay Kits SCC920Ra CLIA Kit for Platelet Derived Growth Factor C (PDGFC) Chemiluminescent immunoassay for Antigen Detection.
SEC920Ra ELISA Kit for Platelet Derived Growth Factor C (PDGFC) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract."Biochim. Biophys. Acta 1492:196-202(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family."FEBS Lett. 475:97-102(2000) [PubMed] [Europe PMC] [Abstract]
  3. "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes."Circulation 103:2242-2247(2001) [PubMed] [Europe PMC] [Abstract]
  10. "PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors."Oncogene 20:626-633(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells."Biochem. Biophys. Res. Commun. 296:604-611(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization."Int. J. Biochem. Cell Biol. 34:414-426(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines."Oncogene 21:3847-3854(2002) [PubMed] [Europe PMC] [Abstract]
  14. "PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases."J. Am. Soc. Nephrol. 14:1145-1153(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure."J. Biol. Chem. 278:17114-17120(2003) [PubMed] [Europe PMC] [Abstract]
  16. "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle."Arterioscler. Thromb. Vasc. Biol. 24:787-792(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Tissue plasminogen activator is a potent activator of PDGF-CC."EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1."J. Biol. Chem. 279:40289-40295(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family."FEBS J. 272:5723-5741(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator."J. Biol. Chem. 280:26856-26862(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts."J. Cell. Physiol. 202:510-517(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma."Proc. Natl. Acad. Sci. U.S.A. 102:3389-3394(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation."Am. J. Respir. Cell Mol. Biol. 34:746-753(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."Exp. Cell Res. 312:782-795(2006) [PubMed] [Europe PMC] [Abstract]
  25. "PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines."Invest. Ophthalmol. Vis. Sci. 48:5722-5732(2007) [PubMed] [Europe PMC] [Abstract]
  26. "Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata."Fertil. Steril. 89:468-471(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy."Invest. Ophthalmol. Vis. Sci. 49:42-48(2008) [PubMed] [Europe PMC] [Abstract]