Fibroblast Growth Factor 21 (FGF21)
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Fibroblast growth factor 21 is a member of the fibroblast growth factor (FGF) family. FGF21 stimulates glucose uptake in adipocytes but not in other cell types.This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway.
FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Treatment of animals with FGF21 results in increased energy expenditure, fat utilization and lipid excretion.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC918Mu02 | Recombinant Fibroblast Growth Factor 21 (FGF21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC918Mu02 | Polyclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. |
| PAC918Mu01 | Polyclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. | |
| Assay Kits | SCC918Mu | CLIA Kit for Fibroblast Growth Factor 21 (FGF21) | Chemiluminescent immunoassay for Antigen Detection. |
| CEC918Mu | ELISA Kit for Fibroblast Growth Factor 21 (FGF21) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| HEC918Mu | High Sensitive ELISA Kit for Fibroblast Growth Factor 21 (FGF21) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEC918Mu | ELISA Kit for Fibroblast Growth Factor 21 (FGF21) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC918Ra01 | Recombinant Fibroblast Growth Factor 21 (FGF21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC918Ra02 | Recombinant Fibroblast Growth Factor 21 (FGF21) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC918Ra01 | Active Fibroblast Growth Factor 21 (FGF21) | Cell culture; Activity Assays. | |
| EPC918Ra61 | Eukaryotic Fibroblast Growth Factor 21 (FGF21) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APC918Ra61 | Active Fibroblast Growth Factor 21 (FGF21) | Cell culture; Activity Assays. | |
| Antibodies | PAC918Ra01 | Polyclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. |
| MAC918Ra21 | Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. | |
| PAC918Ra02 | Polyclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. | |
| Assay Kits | CEC918Ra | ELISA Kit for Fibroblast Growth Factor 21 (FGF21) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CCC918Ra | CLIA Kit for Fibroblast Growth Factor 21 (FGF21) | Chemiluminescent immunoassay for Antigen Detection. | |
| SEC918Ra | ELISA Kit for Fibroblast Growth Factor 21 (FGF21) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC918Po01 | Recombinant Fibroblast Growth Factor 21 (FGF21) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC918Po01 | Polyclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. |
| MAC918Po21 | Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC918Po | ELISA Kit for Fibroblast Growth Factor 21 (FGF21) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC918Po | CLIA Kit for Fibroblast Growth Factor 21 (FGF21) | Chemiluminescent immunoassay for Antigen Detection. |
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- "Different roles of N- and C- termini in the functional activity of FGF21."J. Cell. Physiol. 219:227-234(2009) [PubMed] [Europe PMC] [Abstract]
- "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]