≡

Regucalcin (RGN)

[Edit]

RC; SMP30; GNL; Senescence Marker Protein-30; Gluconolactonase

Regucalcin (RGN)
CCC C765
HGNC 9989
MGI 108024
PubMed 15702226
RGD 3560
UniProt Q15493
Wiki Regucalcin
Regucalcinis a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
Regucalcin is a proposed name for a calcium-binding protein that was discovered in 1978.Regucalcin differs from calmodulin and other Ca2+-related proteins as it does not contain an EF-hand motif of Ca2+-binding domain. It may regulate the effect of Ca2+ on liver cell functions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC765Hu01 Recombinant Regucalcin (RGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC765Hu01 Polyclonal Antibody to Regucalcin (RGN) WB; IHC
MAC765Hu21 Monoclonal Antibody to Regucalcin (RGN) WB; IHC; ICC; IP.
Assay Kits SEC765Hu ELISA Kit for Regucalcin (RGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC765Mu01 Recombinant Regucalcin (RGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC765Mu01 Polyclonal Antibody to Regucalcin (RGN) WB,ICC/IF
Assay Kits SEC765Mu ELISA Kit for Regucalcin (RGN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC765Ra01 Recombinant Regucalcin (RGN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC765Ra01 Polyclonal Antibody to Regucalcin (RGN) WB; IHC
Assay Kits n/a CLIA Kit for Regucalcin (RGN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regucalcin (RGN) ELISA Kit Customized Service Offer
  1. "Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome."Biochim. Biophys. Acta 1263:249-252(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin."Int. J. Mol. Med. 5:283-287(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions."Biochemistry 49:3436-3444(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase."PLoS ONE 8:E53706-E53706(2013) [PubMed] [Europe PMC] [Abstract]