≡

Anoctamin 2 (ANO2)

[Edit]

TMEM16B; C12orf3; Transmembrane Protein 16B(Eight Membrane-Spanning Domains)

Anoctamin 2 (ANO2)
CCC C703
HGNC 1183
MGI 2387214
PubMed 21890523
UniProt Q9NQ90
By database searching with the sequence of TMEM16A as query, Katoh and Katoh (2003) identified TMEM16B. The deduced 999-amino acid TMEM16B protein shares 58.4% sequence identity with TMEM16A. Like TMEM16A, TMEM16B contains 8 potential transmembrane regions with the N- and C-terminal tails facing the cytoplasm and an N-linked glycosylation site in the fourth extracellular loop.
By sequence analysis, Katoh and Katoh (2003) mapped the TMEM16B gene to chromosome 12p13.Acts as a calcium-activated chloride channel (CaCC), mostly in photoreceptors. May mediate olfactory amplification in olfactory sensory neurons (OSNs) and light perception amplification in retina.Retina, especially in the photoreceptor synaptic terminals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC703Hu01 Recombinant Anoctamin 2 (ANO2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC703Hu01 Polyclonal Antibody to Anoctamin 2 (ANO2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Anoctamin 2 (ANO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 2 (ANO2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC703Mu01 Recombinant Anoctamin 2 (ANO2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Anoctamin 2 (ANO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 2 (ANO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 2 (ANO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 2 (ANO2) ELISA Kit Customized Service Offer
  1. "TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals."J. Neurosci. 29:6809-6818(2009) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction."Exp. Physiol. 97:193-199(2012) [PubMed] [Europe PMC] [Abstract]