Norepinephrine Transporter (NET)
[Edit]SLC6A2; NAT1; NET; NET1; Sodium-dependent noradrenaline transporter; Noradrenaline Transporter; Solute Carrier Family 6 member 2; Neurotransmitter transporter; Noradrenalin
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The norepinephrine transporter or NET is a monoamine transporter that transports the neurotransmitter norepinephrine (noradrenaline) from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree.
"The norepinephrine transporter (NET) protein consists of 617 amino acids and has 12 transmembrane domains" and is encoded by the SLC6A2 gene. Certain antidepressant medications act to raise noradrenaline, such as the SNRIs and the tricyclic antidepressants (TCAs). In other words, these medications prevent the noradrenaline transporter from doing its job. Noradrenaline therefore remains in the synapse longer, allowing it to reach more normal levels.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC681Hu01 | Recombinant Norepinephrine Transporter (NET) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC681Hu01 | Polyclonal Antibody to Norepinephrine Transporter (NET) | WB; IHC; ICC; IP. |
| MAC681Hu21 | Monoclonal Antibody to Norepinephrine Transporter (NET) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC681Hu | ELISA Kit for Norepinephrine Transporter (NET) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC681Mu01 | Recombinant Norepinephrine Transporter (NET) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC681Mu02 | Recombinant Norepinephrine Transporter (NET) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC681Mu01 | Polyclonal Antibody to Norepinephrine Transporter (NET) | WB; IHC; ICC; IP. |
| PAC681Mu02 | Polyclonal Antibody to Norepinephrine Transporter (NET) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC681Mu | ELISA Kit for Norepinephrine Transporter (NET) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC681Ra01 | Recombinant Norepinephrine Transporter (NET) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC681Ra01 | Polyclonal Antibody to Norepinephrine Transporter (NET) | WB; IHC; ICC; IP. |
| MAC681Ra21 | Monoclonal Antibody to Norepinephrine Transporter (NET) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC681Ra | ELISA Kit for Norepinephrine Transporter (NET) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter."Nature 350:350-354(1991) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and organization of the coding region of the human norepinephrine transporter gene."Biochem. Biophys. Res. Commun. 215:1145-1150(1995) [PubMed] [Europe PMC] [Abstract]
- "The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons."Biochim. Biophys. Acta 1398:365-370(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
- "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1."Neuron 30:121-134(2001) [PubMed] [Europe PMC] [Abstract]
- "Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency."N. Engl. J. Med. 342:541-549(2000) [PubMed] [Europe PMC] [Abstract]