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Dystrophia Myotonica Protein Kinase (DMPK)

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DM; DM1; DM1PK; DMK; MDPK; MT-PK; Myotonic Dystrophy Protein Kinase; Myotonin-Protein Kinase; Dystrophia Myotonica 1; Thymopoietin Homolog

Dystrophia Myotonica Protein Kinase (DMPK)
CCC C645
HGNC 2933
MGI 94906
PubMed 16193250
RGD 1309825
UniProt Q09013
Wiki MTPK
Myotonic dystrophy protein kinase is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC645Hu01 Recombinant Dystrophia Myotonica Protein Kinase (DMPK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC645Hu01 Polyclonal Antibody to Dystrophia Myotonica Protein Kinase (DMPK) WB; IHC; ICC; IP.
Assay Kits SEC645Hu ELISA Kit for Dystrophia Myotonica Protein Kinase (DMPK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC645Mu01 Recombinant Dystrophia Myotonica Protein Kinase (DMPK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dystrophia Myotonica Protein Kinase (DMPK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dystrophia Myotonica Protein Kinase (DMPK) Polyclonal Antibody Customized Service Offer
Assay Kits SEC645Mu ELISA Kit for Dystrophia Myotonica Protein Kinase (DMPK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC645Ra01 Recombinant Dystrophia Myotonica Protein Kinase (DMPK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC645Ra01 Polyclonal Antibody to Dystrophia Myotonica Protein Kinase (DMPK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dystrophia Myotonica Protein Kinase (DMPK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dystrophia Myotonica Protein Kinase (DMPK) ELISA Kit Customized Service Offer
  1. "An unstable triplet repeat in a gene related to myotonic muscular dystrophy."Science 255:1256-1258(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and transcriptional units at the myotonic dystrophy locus."Genomics 18:673-679(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene."Hum. Mol. Genet. 2:299-304(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy."Science 260:235-238(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells."FEBS Lett. 351:22-26(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism." Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member." Cell 68:799-808(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Different expression of the myotonin protein kinase gene in discrete areas of human brain."Biochem. Biophys. Res. Commun. 216:489-494(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs."Nat. Genet. 1:261-266(1992) [PubMed] [Europe PMC] [Abstract]
  12. "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase."J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition."Biochemistry 39:8480-8490(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase."FEBS Lett. 475:273-277(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties."Hum. Mol. Genet. 9:605-616(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Phospholemman is a substrate for myotonic dystrophy protein kinase."J. Biol. Chem. 275:23362-23367(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity."FEBS Lett. 493:80-84(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase."FEBS Lett. 546:281-287(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum."J. Biol. Chem. 280:8016-8021(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors."Mol. Cell. Biol. 25:1402-1414(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Highly unstable sequence interruptions of the CTG repeat in the myotonic dystrophy gene."Am. J. Med. Genet. A 149:1365-1374(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase."FEBS Lett. 585:1260-1268(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Myotonic dystrophy protein kinase is critical for nuclear envelope integrity."J. Biol. Chem. 286:40296-40306(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase."Acta Crystallogr. D 60:2336-2339(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase."FASEB J. 20:1142-1151(2006) [PubMed] [Europe PMC] [Abstract]
  26. "Structure of dystrophia myotonica protein kinase."Protein Sci. 18:782-791(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]