≡

YY1 Associated Factor 2 (YAF2)

[Edit]

YY1 Associated Factor 2 (YAF2)
CCC C610
HGNC 17363
MGI 1914307
PubMed 12706874
RGD 1582851
UniProt Q8IY57
Wiki YAF2
YY1-associated factor 2 is a protein interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.
YAF2 mRNA increased during the in vitro differentiation of rat skeletal and cardiac muscle cells, in contrast to the downregulation of YY1. Overexpression of YAF2 in mouse myoblast cells stimulated myogenic promoter activity. Cotransfection and expression of YY1 in these cells reversed the stimulatory effect of YAF2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC610Hu01 Recombinant YY1 Associated Factor 2 (YAF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC610Hu01 Polyclonal Antibody to YY1 Associated Factor 2 (YAF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for YY1 Associated Factor 2 (YAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for YY1 Associated Factor 2 (YAF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC610Mu01 Recombinant YY1 Associated Factor 2 (YAF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC610Mu01 Polyclonal Antibody to YY1 Associated Factor 2 (YAF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for YY1 Associated Factor 2 (YAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for YY1 Associated Factor 2 (YAF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC610Ra01 Recombinant YY1 Associated Factor 2 (YAF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC610Ra01 Polyclonal Antibody to YY1 Associated Factor 2 (YAF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for YY1 Associated Factor 2 (YAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for YY1 Associated Factor 2 (YAF2) ELISA Kit Customized Service Offer
  1. "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1."Nucleic Acids Res. 25:843-849(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional interaction of Yaf2 with the central region of MycN."Oncogene 20:5913-5919(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells."Science 296:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Yaf2 inhibits Myc biological function."Cancer Lett. 193:171-176(2003) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the ZF-RANBP domain of YY1-associated factor 2."Submitted (JUN-2006) to the PDB data bank