≡

Valosin Containing Protein (VCP)

[Edit]

IBMPFD; p97; TERA; Transitional Endoplasmic Reticulum ATPase; 15S Mg(2+)-ATPase p97 subunit

Valosin Containing Protein (VCP)
CCC C601
HGNC 12666
MGI 99919
PubMed 11483959
RGD 621595
UniProt P55072
Wiki VCP
VCP is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
Clathrin is a structural protein found in coated pits and vesicles, organelles which are important in membrane trafficking functions such as endocytosis and Golgi sorting. A 100-kD protein, designated valosin-containing protein or VCP by early investigators, is a structural protein complexed with clathrin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC601Hu01 Recombinant Valosin Containing Protein (VCP) Positive Control; Immunogen; SDS-PAGE; WB.
APC601Hu01 Active Valosin Containing Protein (VCP) Cell culture; Activity Assays.
Antibodies PAC601Hu01 Polyclonal Antibody to Valosin Containing Protein (VCP) WB,IHC
MAC601Hu21 Monoclonal Antibody to Valosin Containing Protein (VCP) WB; IHC; ICC; IP.
Assay Kits SEC601Hu ELISA Kit for Valosin Containing Protein (VCP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC601Mu01 Recombinant Valosin Containing Protein (VCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Valosin Containing Protein (VCP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Valosin Containing Protein (VCP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Valosin Containing Protein (VCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Valosin Containing Protein (VCP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC601Ra01 Recombinant Valosin Containing Protein (VCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC601Ra01 Polyclonal Antibody to Valosin Containing Protein (VCP) WB; IHC; ICC; IP.
MAC601Ra21 Monoclonal Antibody to Valosin Containing Protein (VCP) WB; IHC; ICC; IP.
Assay Kits SEC601Ra ELISA Kit for Valosin Containing Protein (VCP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (NOV-2005) to UniProtKB
  7. "Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein."Nature 365:459-462(1993) [PubMed] [Europe PMC] [Abstract]