Virus Induced Signaling Adapter (VISA)
[Edit]CARDIF; IPS1; MAVS; Mitochondrial Antiviral-Signaling Protein; Interferon beta promoter stimulator protein 1; CARD Adaptor Inducing IFN-beta; NF-kappa-B-activating protein 031N
![Virus Induced Signaling Adapter (VISA)](/upload/item/img/Virus-Induced-Signaling-Adapter-(VISA)-92597.jpg)
These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB , or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC597Hu01 | Recombinant Virus Induced Signaling Adapter (VISA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC597Hu01 | Polyclonal Antibody to Virus Induced Signaling Adapter (VISA) | WB; IHC; ICC; IP. |
MAC597Hu21 | Monoclonal Antibody to Virus Induced Signaling Adapter (VISA) | WB; IHC; ICC; IP. | |
Assay Kits | SEC597Hu | ELISA Kit for Virus Induced Signaling Adapter (VISA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCC597Hu | CLIA Kit for Virus Induced Signaling Adapter (VISA) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC597Mu01 | Recombinant Virus Induced Signaling Adapter (VISA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC597Mu01 | Polyclonal Antibody to Virus Induced Signaling Adapter (VISA) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Virus Induced Signaling Adapter (VISA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Virus Induced Signaling Adapter (VISA) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC597Ra01 | Recombinant Virus Induced Signaling Adapter (VISA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC597Ra01 | Polyclonal Antibody to Virus Induced Signaling Adapter (VISA) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Virus Induced Signaling Adapter (VISA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Virus Induced Signaling Adapter (VISA) | ELISA Kit Customized Service Offer |
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