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Glucocerebrosidase (GBA)

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GBA1; GCB; GLUC; Imiglucerase; Alglucerase; Beta-glucocerebrosidase; Glucosidase Beta, Acid; β-Glucosidase; D-Glucosyl-N-Acylsphingosine Glucohydrolase

Glucocerebrosidase (GBA)
CCC C511
HGNC 4177
MGI 95665
PubMed 8548554
UniProt P04062
Wiki GBA

Glucocerebrosidase is an enzyme (EC 3.2.1.45) that is needed to cleave, by hydrolysis, the beta-glucosidic linkage of the chemical glucocerebroside, an intermediate in glycolipid metabolism. It is localized in the lysosome and has a molecular weight of 59700 Daltons. In November 2008 GBA was the gene with the strongest association with Parkinson's disease in the PDGene database The initial study that examined this link was published in 2004.
Mutations in the gene cause Gaucher's disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants encoding the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC511Hu01 Recombinant Glucocerebrosidase (GBA) Positive Control; Immunogen; SDS-PAGE; WB.
RPC511Hu02 Recombinant Glucocerebrosidase (GBA) Positive Control; Immunogen; SDS-PAGE; WB.
RPC511Hu03 Recombinant Glucocerebrosidase (GBA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC511Hu01 Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IP.
MAC511Hu22 Monoclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IP.
PAC511Hu02 Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IP.
LAC511Hu71 Biotin-Linked Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC.
LAC511Hu72 Biotin-Linked Monoclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC.
PAC511Hu03 Polyclonal Antibody to Glucocerebrosidase (GBA) WB
Assay Kits SEC511Hu ELISA Kit for Glucocerebrosidase (GBA) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC511Hu CLIA Kit for Glucocerebrosidase (GBA) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC511Mu01 Recombinant Glucocerebrosidase (GBA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC511Mu01 Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IP.
LAC511Mu81 FITC-Linked Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IF.
LAC511Mu71 Biotin-Linked Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Glucocerebrosidase (GBA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucocerebrosidase (GBA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC511Ra01 Recombinant Glucocerebrosidase (GBA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC511Ra01 Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IP.
LAC511Ra81 FITC-Linked Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC; IF.
LAC511Ra71 Biotin-Linked Polyclonal Antibody to Glucocerebrosidase (GBA) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Glucocerebrosidase (GBA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucocerebrosidase (GBA) ELISA Kit Customized Service Offer
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