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Chimerin 2 (CHN2)

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ARHGAP3; BCH; RHoGAP3; Chimaerin; Beta-Chimaerin; Beta-chimerin; Rho GTPase-activating protein 3

Chimerin 2 (CHN2)
CCC C420
HGNC 1944
MGI 1917243
PubMed 8440677
RGD 620140
UniProt P52757
Wiki Chimerin_2

Beta-chimaerin is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane.

The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC420Hu01 Recombinant Chimerin 2 (CHN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC420Hu01 Polyclonal Antibody to Chimerin 2 (CHN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chimerin 2 (CHN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chimerin 2 (CHN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC420Mu01 Recombinant Chimerin 2 (CHN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC420Mu01 Polyclonal Antibody to Chimerin 2 (CHN2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chimerin 2 (CHN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chimerin 2 (CHN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC420Ra01 Recombinant Chimerin 2 (CHN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC420Ra01 Polyclonal Antibody to Chimerin 2 (CHN2) WB,IHC
Assay Kits n/a CLIA Kit for Chimerin 2 (CHN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chimerin 2 (CHN2) ELISA Kit Customized Service Offer
  1. "Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain."J. Biol. Chem. 269:12888-12892(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma."Cancer Res. 55:3456-3461(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin."Cell 119:407-418(2004) [PubMed] [Europe PMC] [Abstract]