Anterior Gradient 2 (AGR2)
[Edit]GOB4; HAG2; XAG2; AG2; PDIA17; HPC8; Anterior Gradient Protein 2; Protein Disulfide Isomerase Family A,Member 17; Secreted cement gland protein XAG-2 homolog
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Anterior gradient homolog 2 (AGR2) is a human protein originally discovered in Xenopus laevis, encoded for by the gene of the same name. In Xenopus AGR2 plays a role in cement gland differentiation, however in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response and AGR2 levels are elevated in the preneoplastic tissue Barrett's oesophagus.
The deduced 175-amino acid soluble AGR2 protein, which is 91% identical to the mouse protein and 47% identical to the frog protein, contains a signal peptide. Northern blot analysis revealed strongest expression of 0.9- and 1.6-kb AGR2 transcripts in lung and in all ER-positive breast carcinoma lines tested; weaker expression was detected in pancreas.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC285Hu01 | Recombinant Anterior Gradient 2 (AGR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC285Hu01 | Polyclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC; IP. |
| MAC285Hu21 | Monoclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC; IP. | |
| LAC285Hu72 | Biotin-Linked Monoclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC. | |
| LAC285Hu71 | Biotin-Linked Polyclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC. | |
| PAC285Hu02 | Polyclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC285Hu | ELISA Kit for Anterior Gradient 2 (AGR2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC285Hu | CLIA Kit for Anterior Gradient 2 (AGR2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC285Mu01 | Recombinant Anterior Gradient 2 (AGR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC285Mu01 | Polyclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC; IP. |
| LAC285Mu71 | Biotin-Linked Polyclonal Antibody to Anterior Gradient 2 (AGR2) | WB; IHC; ICC. | |
| Assay Kits | SEC285Mu | ELISA Kit for Anterior Gradient 2 (AGR2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
- "hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines."Biochem. Biophys. Res. Commun. 251:111-116(1998) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan."Br. J. Cancer 88:579-585(2003) [PubMed] [Europe PMC] [Abstract]
- "AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer."Genes Chromosomes Cancer 43:249-259(2005) [PubMed] [Europe PMC] [Abstract]
- "The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation."Cancer Res. 68:492-497(2008) [PubMed] [Europe PMC] [Abstract]
- "The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]