Bleomycin Hydrolase (BLMH)
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. The protein had aminopeptidase activity that was blocked by the irreversible cysteine protease inhibitor E-64. Both yeast and human BMH also possess endopeptidase activity. The gene is expressed in many human tissues with elevated expression levels found in testis, skeletal muscle, and pancreas, and low levels of expression in colon and peripheral blood leukocytes

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC220Hu01 Recombinant Bleomycin Hydrolase (BLMH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC220Hu01 Polyclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC; IP; FCM
MAC220Hu22 Monoclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC; IP.
LAC220Hu71 Biotin-Linked Polyclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC.
LAC220Hu81 FITC-Linked Polyclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC; IF.
Assay Kits SEC220Hu ELISA Kit for Bleomycin Hydrolase (BLMH) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC220Hu CLIA Kit for Bleomycin Hydrolase (BLMH) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC220Mu01 Recombinant Bleomycin Hydrolase (BLMH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC220Mu01 Polyclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bleomycin Hydrolase (BLMH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bleomycin Hydrolase (BLMH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC220Ra01 Recombinant Bleomycin Hydrolase (BLMH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC220Ra01 Polyclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC; IP.
LAC220Ra71 Biotin-Linked Polyclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC.
MAC220Ra21 Monoclonal Antibody to Bleomycin Hydrolase (BLMH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bleomycin Hydrolase (BLMH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bleomycin Hydrolase (BLMH) ELISA Kit Customized Service Offer
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  7. "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease."Structure 7:619-627(1999) [PubMed] [Europe PMC] [Abstract]