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E1A Binding Protein P300 (EP300)

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KAT3B; p300; Histone Acetyltransferase p300

E1A Binding Protein P300 (EP300)
CCC C216
HGNC 3373
MGI 1276116
PubMed 10700188
RGD 620036
UniProt Q09472
Wiki EP300
E1A binding protein p300 also known as EP300 or p300 is a protein which in humans is encoded by the EP300 gene.This protein regulates the activity of many genes in tissues throughout the body. It plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.
The p300 protein carries out its function by activating transcription, the process of making a blueprint of a gene for protein production. Specifically, p300 connects transcription factors, which are proteins that start the transcription process, with the complex of proteins that carries out transcription in the cell's nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC216Hu01 Recombinant E1A Binding Protein P300 (EP300) Positive Control; Immunogen; SDS-PAGE; WB.
RPC216Hu02 Recombinant E1A Binding Protein P300 (EP300) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC216Hu01 Polyclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
MAC216Hu22 Monoclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
PAC216Hu02 Polyclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
Assay Kits SEC216Hu ELISA Kit for E1A Binding Protein P300 (EP300) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC216Mu01 Recombinant E1A Binding Protein P300 (EP300) Positive Control; Immunogen; SDS-PAGE; WB.
RPC216Mu02 Recombinant E1A Binding Protein P300 (EP300) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC216Mu01 Polyclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
PAC216Mu02 Polyclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
Assay Kits SEC216Mu ELISA Kit for E1A Binding Protein P300 (EP300) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC216Ra01 Recombinant E1A Binding Protein P300 (EP300) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC216Ra01 Polyclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
MAC216Ra21 Monoclonal Antibody to E1A Binding Protein P300 (EP300) WB; IHC; ICC; IP.
Assay Kits SEC216Ra ELISA Kit for E1A Binding Protein P300 (EP300) Enzyme-linked immunosorbent assay for Antigen Detection.
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  40. "P300 transcriptional repression is mediated by SUMO modification."Mol. Cell 11:1043-1054(2003) [PubMed] [Europe PMC] [Abstract]
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  42. "Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53."Cell 117:735-748(2004) [PubMed] [Europe PMC] [Abstract]
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  47. "Regulation of the p300 HAT domain via a novel activation loop."Nat. Struct. Mol. Biol. 11:308-315(2004) [PubMed] [Europe PMC] [Abstract]
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  50. "Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease."Am. J. Hum. Genet. 76:572-580(2005) [PubMed] [Europe PMC] [Abstract]
  51. "SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1."J. Biol. Chem. 280:10264-10276(2005) [PubMed] [Europe PMC] [Abstract]
  52. "The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription."Mol. Endocrinol. 19:2283-2298(2005) [PubMed] [Europe PMC] [Abstract]
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  58. "Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription."Mol. Cell. Biol. 26:1770-1785(2006) [PubMed] [Europe PMC] [Abstract]
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  60. ErratumProc. Natl. Acad. Sci. U.S.A. 110:4147-4148(2013)
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  84. "Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development."Mol. Cell 56:261-274(2014) [PubMed] [Europe PMC] [Abstract]
  85. "CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis."Nucleic Acids Res. 42:8433-8448(2014) [PubMed] [Europe PMC] [Abstract]
  86. "Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress."Nucleic Acids Res. 42:11447-11461(2014) [PubMed] [Europe PMC] [Abstract]
  87. "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha."Proc. Natl. Acad. Sci. U.S.A. 99:5367-5372(2002) [PubMed] [Europe PMC] [Abstract]
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  92. "Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation."Nat. Struct. Mol. Biol. 20:1040-1046(2013) [PubMed] [Europe PMC] [Abstract]
  93. "Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues."Biochemistry 53:3415-3422(2014) [PubMed] [Europe PMC] [Abstract]
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