Neurocan (NCAN)
[Edit]CSPG3; NEUR; Neurocan Core Protein; Chondroitin Sulfate Proteoglycan 3; Neurocan Proteoglycan
Neurocan was first described in the early postnatal rat brain where it accounts for 20 to 30% of the total chondroitin sulfate proteoglycan. Rauch et al. (1992) cloned the rat cDNA using degenerate primers based on partial amino acid sequence of immunoaffinity-purified protein. The mouse neurocan cDNA encodes a deduced 1,257-amino acid protein with a predicted molecular mass of 136 kD. The large protein is processed into a smaller form in the adult brain. The predicted protein has a 22-amino acid signal peptide followed by an immunoglobin-like domain and repeating motifs characteristic of the hyaluronic acid-binding region of aggregating proteoglycans. The C terminus shows approximately 60% identity to the fibroblast and cartilage proteoglycans versican and aggreca).
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC178Hu01 | Recombinant Neurocan (NCAN) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC178Hu01 | Polyclonal Antibody to Neurocan (NCAN) | WB; IHC; ICC; IP. |
Assay Kits | SEC178Hu | ELISA Kit for Neurocan (NCAN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC178Mu01 | Recombinant Neurocan (NCAN) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC178Mu01 | Polyclonal Antibody to Neurocan (NCAN) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Neurocan (NCAN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Neurocan (NCAN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC178Ra01 | Recombinant Neurocan (NCAN) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC178Ra01 | Polyclonal Antibody to Neurocan (NCAN) | WB; IHC; ICC; IP. |
MAC178Ra21 | Monoclonal Antibody to Neurocan (NCAN) | WB; IHC; ICC; IP. | |
Assay Kits | SEC178Ra | ELISA Kit for Neurocan (NCAN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Characterization of the human neurocan gene, CSPG3."Gene 221:199-205(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]