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Fibroblast Growth Factor Receptor Substrate 2 (FRS2)

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SNT1; FRS2A; FRS2Alpha; SNT; SNT-1; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1

Fibroblast Growth Factor Receptor Substrate 2 (FRS2)
CCC C063
HGNC 16971
MGI 1100860
PubMed 10629055
RGD 1308201
UniProt Q8WU20
Wiki FRS2

The deduced 508-amino acid protein has a predicted molecular mass of 56.8 kD. It contains a myristylation sequence, a phosphotyrosine-binding (PTB) domain, and 4 potential GRB2-binding sites. Northern blot analysis of adult mouse tissues detected ubiquitous expression of Frs2, with highest levels in brain, kidney, lung, ovary, and testis. SDS-PAGE showed that FRS2 migrates as doublet of 92 to 95 kD.

Melillo et al. (2001) presented evidence that FRS2 couples both ligand-regulated and oncogenic forms of RET with the MAPK signaling cascade under normal biologic conditions and pathologic conditions, such as multiple endocrine neoplasias and papillary thyroid carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC063Hu01 Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC063Hu01 Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC063Mu01 Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC063Mu01 Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC063Ra01 Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC063Ra01 Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit Customized Service Offer
  1. "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins."J. Biol. Chem. 273:17987-17990(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation."J. Biol. Chem. 274:9861-9870(1999) [PubMed] [Europe PMC] [Abstract]
  6. "EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2."Biol. Chem. 384:1215-1226(2003) [PubMed] [Europe PMC] [Abstract]
  7. "TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma."Cancer Cell 6:347-360(2004) [PubMed] [Europe PMC] [Abstract]
  8. "ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation."FEBS Lett. 581:727-734(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function."EMBO J. 30:3259-3273(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins."Cancer Sci. 99:1319-1325(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors."Mol. Cell 6:921-929(2000) [PubMed] [Europe PMC] [Abstract]