![Endomorphin 1 (EM1)](/upload/item/img/Endomorphin-1-(EM1)-92062.jpg)
CCC | C062 |
CAS | 189388-22-5 |
PubMed | 11404430 |
Endomorphins are two endogenous opioid peptides. Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are tetrapeptides with the highest known affinity and specificity for the opioid receptor. Endomorphin-1 is located in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors. Endomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP. However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | CPC062Mi21 | OVA Conjugated Endomorphin 1 (EM1) | Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Endomorphin 1 (EM1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Endomorphin 1 (EM1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Endomorphin 1 (EM1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Endomorphin 1 (EM1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | CPC062Mi21 | OVA Conjugated Endomorphin 1 (EM1) | Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Endomorphin 1 (EM1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Endomorphin 1 (EM1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Endomorphin 1 (EM1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Endomorphin 1 (EM1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | CPC062Mi21 | OVA Conjugated Endomorphin 1 (EM1) | Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Endomorphin 1 (EM1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Endomorphin 1 (EM1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Endomorphin 1 (EM1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Endomorphin 1 (EM1) | ELISA Kit Customized Service Offer |