≡

S100 Calcium Binding Protein P (S100P)

[Edit]

S100-P; MIG9; S100-E; Migration-inducing gene 9 protein

S100 Calcium Binding Protein P (S100P)
CCC C054
HGNC 10504
PubMed 10639564
UniProt P25815
Wiki S100P

S100P is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2 , also binds Zn2 and Mg2 . This protein may play a role in the etiology of prostate cancer.

S100P showed a pattern of expression similar to that of S100PBP in both healthy pancreas and pancreatic cancer. Immunohistochemical analysis showed that S100P expression correlated significantly with increasing grade of pancreatic intraepithelial neoplasia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC054Hu01 Recombinant S100 Calcium Binding Protein P (S100P) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC054Hu01 Polyclonal Antibody to S100 Calcium Binding Protein P (S100P) WB; IHC; IF
MAC054Hu22 Monoclonal Antibody to S100 Calcium Binding Protein P (S100P) WB
LAC054Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein P (S100P) WB; IHC; ICC.
LAC054Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein P (S100P) WB; IHC; ICC; IF.
MAC054Hu21 Monoclonal Antibody to S100 Calcium Binding Protein P (S100P) WB; IHC; ICC; IP.
MAC054Hu23 Monoclonal Antibody to S100 Calcium Binding Protein P (S100P) WB; IHC; ICC; IP.
MAC054Hu24 Monoclonal Antibody to S100 Calcium Binding Protein P (S100P) WB; IHC; ICC; IP.
Assay Kits SEC054Hu ELISA Kit for S100 Calcium Binding Protein P (S100P) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties."Eur. J. Biochem. 207:541-547(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Purification and characterization of a new member of the S-100 protein family from human placenta."Biochem. Biophys. Res. Commun. 182:1246-1253(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P."Mol. Biol. Cell 14:2372-2384(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein."Mol. Biol. Rep. 30:243-248(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Heterodimeric interaction and interfaces of S100A1 and S100P."Biochem. J. 382:375-383(2004) [PubMed] [Europe PMC] [Abstract]
  7. "S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE)."J. Biol. Chem. 279:5059-5065(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer."Am. J. Pathol. 166:81-92(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Generation and characterization of a novel, permanently active S100P mutant."Biochim. Biophys. Acta 1793:1078-1085(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The crystal structure at 2A resolution of the Ca2+ -binding protein S100P."J. Mol. Biol. 325:785-794(2003) [PubMed] [Europe PMC] [Abstract]
  13. "NMR structure of the Apo-S100P protein."J. Biomol. NMR 29:399-402(2004) [PubMed] [Europe PMC] [Abstract]