Interleukin 22 (IL22)

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ILTIF; Zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; IL-22; Cytokine Zcyto18; IL-10-Related T-Cell-Derived Inducible Factor

Interleukin 22 (IL22)

IL-22, a class of potent mediators of cellular inflammatory responses. It shares us of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28, IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells.

IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells  and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Hu01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
EPC032Hu61 Eukaryotic Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
APC032Hu61 Active Interleukin 22 (IL22) Cell culture; Activity Assays.
APC032Hu01 Active Interleukin 22 (IL22) Cell culture; Activity Assays.
Antibodies PAC032Hu01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
MAC032Hu22 Monoclonal Antibody to Interleukin 22 (IL22) WB
MAC032Hu21 Monoclonal Antibody to Interleukin 22 (IL22) IHC
MAC032Hu23 Monoclonal Antibody to Interleukin 22 (IL22) IHC
Assay Kits SEC032Hu ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC032Hu CLIA Kit for Interleukin 22 (IL22) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Mu01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
RPC032Mu02 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
APC032Mu61 Active Interleukin 22 (IL22) Cell culture; Activity Assays.
Antibodies PAC032Mu01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC
PAC032Mu02 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
Assay Kits SEC032Mu ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC032Mu CLIA Kit for Interleukin 22 (IL22) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Ra01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC032Ra01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
Assay Kits SEC032Ra ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Bo01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
EPC032Bo61 Eukaryotic Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC032Bo01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
MAC032Bo21 Monoclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
Assay Kits SEC032Bo ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of insect-cell-derived IL-22."Acta Crystallogr. D 61:942-950(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of IL-22 bound to its high-affinity IL-22R1 chain."Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
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