Creatine Kinase B (CK-BB)

Brain-type creatine kinase consists of a homodimer of two identical brain-type CK-B subunits. BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. There, CK-BB forms tightly coupled microcompartments for in situ regeneration of ATP that has been used up.

The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in brain, smooth muscle as well as in other tissues and cells such as neuronal cells, retina, kidney, bone etc.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC030Hu01 Recombinant Creatine Kinase B (CK-BB) Positive Control; Immunogen; SDS-PAGE; WB.
APC030Hu01 Active Creatine Kinase B (CK-BB) Cell culture; Activity Assays.
Antibodies PAC030Hu01 Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP; FCM
MAC030Hu22 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Hu21 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Hu23 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Hu24 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Hu25 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Hu27 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Hu29 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
Assay Kits SEC030Hu ELISA Kit for Creatine Kinase B (CK-BB) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC030Hu CLIA Kit for Creatine Kinase B (CK-BB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC030Mu01 Recombinant Creatine Kinase B (CK-BB) Positive Control; Immunogen; SDS-PAGE; WB.
NPC030Mu01 Native Creatine Kinase B (CK-BB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC030Mu02 Recombinant Creatine Kinase B (CK-BB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC030Mu01 Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
PAC030Mu02 Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
Assay Kits SEC030Mu ELISA Kit for Creatine Kinase B (CK-BB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC030Ra01 Recombinant Creatine Kinase B (CK-BB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC030Ra01 Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
LAC030Ra71 Biotin-Linked Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC.
MAC030Ra21 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Ra23 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
MAC030Ra22 Monoclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
Assay Kits SEC030Ra ELISA Kit for Creatine Kinase B (CK-BB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC030Ca01 Recombinant Creatine Kinase B (CK-BB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC030Ca01 Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IP.
LAC030Ca71 Biotin-Linked Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC.
LAC030Ca81 FITC-Linked Polyclonal Antibody to Creatine Kinase B (CK-BB) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Creatine Kinase B (CK-BB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Creatine Kinase B (CK-BB) ELISA Kit Customized Service Offer
  1. "Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number."Biochem. Biophys. Res. Commun. 144:1116-1127(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of the human creatine kinase B gene."Genomics 1:126-137(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci."J. Clin. Invest. 79:1412-1420(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Complete nucleotide sequence of the human creatine kinase B gene."Nucleic Acids Res. 17:6385-6385(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation of a functional human gene for brain creatine kinase."J. Biol. Chem. 263:2442-2446(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Protein analysis of human maculae in relation to age-related maculopathy."Lab. Invest. 73:267-272(1995) [PubMed] [Europe PMC] [Abstract]