Reverse Triiodothyronine (rT3)

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RT3; r-T3; Reverse T3;(2S)-2-Amino-3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3-Iodophenyl]propanoic Acid; 3,3',5'-Triiodo-L-thyronine

Reverse Triiodothyronine (rT3)

Reverse triiodothyronine is a molecule which is an isomer of triiodothyronine (T3). It is derived from thyroxine (T4) through the action of deiodinase.rT3, unlike T3, does not stimulate thyroid hormone receptors. However, rT3 nonetheless binds to these receptors, thereby blocking the action of T3. Under stress conditions, the adrenal glands produce excess amounts of cortisol. Cortisol inhibits the conversion of T4 to T3, thus shunting T4 conversion from T3 towards rT3.

Consequently, there is a widespread shutdown in T3 binding across the body. This condition is termed Reverse T3 Dominance. It results in reduced body temperature, which slows the action of many enzymes, leading to a clinical syndrome, Multiple Enzyme Dysfunction, which produces the effects seen in hypothyroidism. Effects include fatigue, headache, migraine, PMS, irritability, fluid retention, anxiety and panic.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPC022Ge11 BSA Conjugated Reverse Triiodothyronine (rT3) Immunogen; SDS-PAGE; WB.
CPC022Ge21 OVA Conjugated Reverse Triiodothyronine (rT3) Immunogen; SDS-PAGE; WB.
Antibodies PAC022Ge01 Polyclonal Antibody to Reverse Triiodothyronine (rT3) ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
MAC022Ge21 Monoclonal Antibody to Reverse Triiodothyronine (rT3) ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
MAC022Ge22 Monoclonal Antibody to Reverse Triiodothyronine (rT3) ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
MAC022Ge23 Monoclonal Antibody to Reverse Triiodothyronine (rT3) ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
MAC022Ge24 Monoclonal Antibody to Reverse Triiodothyronine (rT3) ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
MAC022Ge25 Monoclonal Antibody to Reverse Triiodothyronine (rT3) ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
Assay Kits CEC022Ge ELISA Kit for Reverse Triiodothyronine (rT3) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC022Ge High Sensitive ELISA Kit for Reverse Triiodothyronine (rT3) Enzyme-linked immunosorbent assay for Antigen Detection.