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Toll Like Receptor 10 (TLR10)

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CD290

Toll Like Receptor 10 (TLR10)
CCC B992
HGNC 15634
PubMed 23370977
UniProt Q9BXR5
Wiki TLR10

Toll-like receptor 10 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB992Hu01 Recombinant Toll Like Receptor 10 (TLR10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB992Hu01 Polyclonal Antibody to Toll Like Receptor 10 (TLR10) WB; IHC; ICC; IP.
MAB992Hu22 Monoclonal Antibody to Toll Like Receptor 10 (TLR10) WB; IHC; ICC; IP.
Assay Kits SEB992Hu ELISA Kit for Toll Like Receptor 10 (TLR10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB992Ra01 Recombinant Toll Like Receptor 10 (TLR10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB992Ra01 Polyclonal Antibody to Toll Like Receptor 10 (TLR10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 10 (TLR10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 10 (TLR10) ELISA Kit Customized Service Offer
  1. "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells."Biochim. Biophys. Acta 1518:157-161(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer."J. Biol. Chem. 283:11861-11865(2008) [PubMed] [Europe PMC] [Abstract]