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Apolipoprotein A4 (APOA4)

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ApoA-IV; ApoAIV; Apo-A4

Apolipoprotein A4 (APOA4)
CCC B967
HGNC 602
MGI 88051
RGD 2132
UniProt P06727

APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequence polymorphisms occur in exon 3. The best validated and studied non-synonymous SNPs are a glutamine => histidine substitution at codon 380 and a threonine => serine substitution at codon 367; a sequence polymorphism has also been identified in the 3'UTR of the third exon. Intra-species comparative gene sequence analysis suggests that the APOA4 gene arose from APOA1 by gene duplication approximately 270 MYA.The primary translation product of the APOA4 gene is a 396-residue preprotein, which undergoes proteolytic processing to yield apo A-IV, a 376-reside mature O-linked glycoprotein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB967Hu01 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB967Hu02 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
APB967Hu02 Active Apolipoprotein A4 (APOA4) Cell culture; Activity Assays.
Antibodies PAB967Hu01 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB,IHC
MAB967Hu22 Monoclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
PAB967Hu02 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB,IHC
Assay Kits SEB967Hu ELISA Kit for Apolipoprotein A4 (APOA4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB967Hu CLIA Kit for Apolipoprotein A4 (APOA4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB967Mu01 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB967Mu02 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB967Mu01 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
PAB967Mu02 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
LAB967Mu71 Biotin-Linked Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC.
LAB967Mu81 FITC-Linked Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IF.
Assay Kits SEB967Mu ELISA Kit for Apolipoprotein A4 (APOA4) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB967Mu High Sensitive ELISA Kit for Apolipoprotein A4 (APOA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB967Ra01 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB967Ra01 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
MAB967Ra21 Monoclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
Assay Kits SEB967Ra ELISA Kit for Apolipoprotein A4 (APOA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB967Po01 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB967Po01 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
LAB967Po81 FITC-Linked Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IF.
LAB967Po71 Biotin-Linked Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC.
MAB967Po21 Monoclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
LAB967Po72 Biotin-Linked Monoclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC.
Assay Kits SEB967Po ELISA Kit for Apolipoprotein A4 (APOA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB967Bo01 Recombinant Apolipoprotein A4 (APOA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB967Bo01 Polyclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
MAB967Bo21 Monoclonal Antibody to Apolipoprotein A4 (APOA4) WB; IHC; ICC; IP.
Assay Kits SEB967Bo ELISA Kit for Apolipoprotein A4 (APOA4) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)."Proc. Natl. Acad. Sci. U.S.A. 83:8457-8461(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of the human apolipoprotein A-IV gene."J. Biol. Chem. 262:7973-7981(1987) [PubMed] [Europe PMC] [Abstract]
  4. "The primary structure of human apolipoprotein A-IV."Biochim. Biophys. Acta 1002:231-237(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster."Hum. Genet. 115:36-56(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III."J. Biol. Chem. 261:1998-2002(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Biosynthesis of human preapolipoprotein A-IV."J. Biol. Chem. 259:468-474(1984) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic polymorphism of apolipoprotein A-IV."Curr. Opin. Lipidol. 2:90-95(1991)
  11. "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene."J. Biol. Chem. 265:10061-10064(1990) [PubMed] [Europe PMC] [Abstract]
  12. "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1."J. Biol. Chem. 265:12734-12739(1990) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The structure of dimeric apolipoprotein A-IV and its mechanism of self-association."Structure 20:767-779(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360."Arterioscler. Thromb. 11:851-856(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."J. Biol. Chem. 266:13513-13518(1991) [PubMed] [Europe PMC] [Abstract]
  17. ErratumJ. Biol. Chem. 266:19866-19866(1991)
  18. "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population."Am. J. Hum. Genet. 50:1115-1128(1992) [PubMed] [Europe PMC] [Abstract]
  19. "A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127."Biochim. Biophys. Acta 1138:27-33(1992) [PubMed] [Europe PMC] [Abstract]
  20. "Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism."Genet. Epidemiol. 9:379-388(1992) [PubMed] [Europe PMC] [Abstract]
  21. "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants."Hum. Mutat. 5:58-65(1995) [PubMed] [Europe PMC] [Abstract]
  22. "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity."Hum. Mutat. 8:319-325(1996) [PubMed] [Europe PMC] [Abstract]
  23. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]