Interleukin 17F (IL17F)

IL-17F has been shown to stimulate prolifertion and activation of T cells and PBMCs, to inhibit angiogenesis as well as to regulate cartilage matrix turnover. This recombinant IL-17F is a homodimeric protein with a total weight of 30.1kDa containing two 134 amino acid residue chains.Using nested RACE PCR with leukocyte-anchored cDNA, Starnes et al. (2001) isolated an IL17F cDNA encoding a 153-amino acid protein that shares 40% homology with IL17.

In addition to the 2 invariant disulfide bonds found in other members of the IL17 family, IL17F contains a signal peptide with an extra cys-cys pair that could function as an extra disulfide bond. Expression of IL17F could not be identified by Northern blot analysis. RT-PCR analysis detected expression in activated, but not resting, CD4+ T cells and activated monocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB955Hu01 Recombinant Interleukin 17F (IL17F) Positive Control; Immunogen; SDS-PAGE; WB.
APB955Hu01 Active Interleukin 17F (IL17F) Cell culture; Activity Assays.
EPB955Hu61 Eukaryotic Interleukin 17F (IL17F) Positive Control; Immunogen; SDS-PAGE; WB.
APB955Hu61 Active Interleukin 17F (IL17F) Cell culture; Activity Assays.
Antibodies PAB955Hu01 Polyclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
MAB955Hu22 Monoclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
LAB955Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC.
LAB955Hu81 FITC-Linked Polyclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IF.
MAB955Hu21 Monoclonal Antibody to Interleukin 17F (IL17F) WB.
MAB955Hu23 Monoclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
Assay Kits SEB955Hu ELISA Kit for Interleukin 17F (IL17F) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB955Hu CLIA Kit for Interleukin 17F (IL17F) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB955Mu01 Recombinant Interleukin 17F (IL17F) Positive Control; Immunogen; SDS-PAGE; WB.
RPB955Mu02 Recombinant Interleukin 17F (IL17F) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB955Mu01 Polyclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
PAB955Mu02 Polyclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
Assay Kits SEB955Mu ELISA Kit for Interleukin 17F (IL17F) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB955Mu CLIA Kit for Interleukin 17F (IL17F) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB955Ra01 Recombinant Interleukin 17F (IL17F) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB955Ra01 Polyclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
MAB955Ra21 Monoclonal Antibody to Interleukin 17F (IL17F) WB; IHC; ICC; IP.
Assay Kits SEB955Ra ELISA Kit for Interleukin 17F (IL17F) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB955Ra CLIA Kit for Interleukin 17F (IL17F) Chemiluminescent immunoassay for Antigen Detection.
  1. "IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production."J. Immunol. 167:4137-4140(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a novel cytokine, ML-1, and its expression in subjects with asthma."J. Immunol. 167:4430-4435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding."EMBO J. 20:5332-5341(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Structural basis of receptor sharing by interleukin 17 cytokines."Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity." Science 332:65-68(2011) [PubMed] [Europe PMC] [Abstract]