IL-17F has been shown to stimulate prolifertion and activation of T cells and PBMCs, to inhibit angiogenesis as well as to regulate cartilage matrix turnover. This recombinant IL-17F is a homodimeric protein with a total weight of 30.1kDa containing two 134 amino acid residue chains.Using nested RACE PCR with leukocyte-anchored cDNA, Starnes et al. (2001) isolated an IL17F cDNA encoding a 153-amino acid protein that shares 40% homology with IL17.
In addition to the 2 invariant disulfide bonds found in other members of the IL17 family, IL17F contains a signal peptide with an extra cys-cys pair that could function as an extra disulfide bond. Expression of IL17F could not be identified by Northern blot analysis. RT-PCR analysis detected expression in activated, but not resting, CD4+ T cells and activated monocytes.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB955Hu01 | Recombinant Interleukin 17F (IL17F) | Positive Control; Immunogen; SDS-PAGE; WB. |
APB955Hu01 | Active Interleukin 17F (IL17F) | Cell culture; Activity Assays. | |
EPB955Hu61 | Eukaryotic Interleukin 17F (IL17F) | Positive Control; Immunogen; SDS-PAGE; WB. | |
APB955Hu61 | Active Interleukin 17F (IL17F) | Cell culture; Activity Assays. | |
Antibodies | PAB955Hu01 | Polyclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. |
MAB955Hu22 | Monoclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. | |
LAB955Hu71 | Biotin-Linked Polyclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC. | |
LAB955Hu81 | FITC-Linked Polyclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IF. | |
MAB955Hu21 | Monoclonal Antibody to Interleukin 17F (IL17F) | WB. | |
MAB955Hu23 | Monoclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. | |
Assay Kits | SEB955Hu | ELISA Kit for Interleukin 17F (IL17F) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCB955Hu | CLIA Kit for Interleukin 17F (IL17F) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB955Mu01 | Recombinant Interleukin 17F (IL17F) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB955Mu02 | Recombinant Interleukin 17F (IL17F) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB955Mu01 | Polyclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. |
PAB955Mu02 | Polyclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. | |
Assay Kits | SEB955Mu | ELISA Kit for Interleukin 17F (IL17F) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCB955Mu | CLIA Kit for Interleukin 17F (IL17F) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB955Ra01 | Recombinant Interleukin 17F (IL17F) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB955Ra01 | Polyclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. |
MAB955Ra21 | Monoclonal Antibody to Interleukin 17F (IL17F) | WB; IHC; ICC; IP. | |
Assay Kits | SEB955Ra | ELISA Kit for Interleukin 17F (IL17F) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCB955Ra | CLIA Kit for Interleukin 17F (IL17F) | Chemiluminescent immunoassay for Antigen Detection. |
- "IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production."J. Immunol. 167:4137-4140(2001) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Identification of a novel cytokine, ML-1, and its expression in subjects with asthma."J. Immunol. 167:4430-4435(2001) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding."EMBO J. 20:5332-5341(2001) [PubMed] [Europe PMC] [Abstract]
- "Structural basis of receptor sharing by interleukin 17 cytokines."Nat. Immunol. 10:1245-1251(2009) [PubMed] [Europe PMC] [Abstract]
- "Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity." Science 332:65-68(2011) [PubMed] [Europe PMC] [Abstract]