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Monoamine Oxidase A (MAOA)

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MAO-A; Amine oxidase [flavin-containing] A

Monoamine Oxidase A (MAOA)
CCC B954
HGNC 6833
MGI 96915
PubMed 1678250
RGD 61898
UniProt P21397
Wiki MAOA

Monoamine oxidase A is an isozyme of monoamine oxidase. It preferentially deaminates norepinephrine (noradrenaline), epinephrine (adrenaline), serotonin, and dopamine (dopamine is equally deaminated by MAO-A and MAO-B). It is inhibited by clorgiline and befloxatone.This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. The gene is adjacent to a related gene (MAOB) on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34 percent in patients with major depressive disorder.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Monoamine Oxidase A (MAOA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Monoamine Oxidase A (MAOA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Monoamine Oxidase A (MAOA) Polyclonal Antibody Customized Service Offer
Assay Kits SEB954Hu ELISA Kit for Monoamine Oxidase A (MAOA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB954Mu01 Recombinant Monoamine Oxidase A (MAOA) Positive Control; Immunogen; SDS-PAGE; WB.
RPB954Mu02 Recombinant Monoamine Oxidase A (MAOA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB954Mu01 Polyclonal Antibody to Monoamine Oxidase A (MAOA) WB; IHC; ICC; IP.
LAB954Mu71 Biotin-Linked Polyclonal Antibody to Monoamine Oxidase A (MAOA) WB; IHC; ICC.
PAB954Mu02 Polyclonal Antibody to Monoamine Oxidase A (MAOA) WB; IHC; ICC; IP.
Assay Kits SEB954Mu ELISA Kit for Monoamine Oxidase A (MAOA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB954Ra01 Recombinant Monoamine Oxidase A (MAOA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB954Ra01 Polyclonal Antibody to Monoamine Oxidase A (MAOA) WB; IHC; ICC; IP.
MAB954Ra21 Monoclonal Antibody to Monoamine Oxidase A (MAOA) WB; IHC; ICC; IP.
MAB954Ra22 Monoclonal Antibody to Monoamine Oxidase A (MAOA) WB; IHC; ICC; IP.
Assay Kits SEB954Ra ELISA Kit for Monoamine Oxidase A (MAOA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences."J. Neurochem. 51:1321-1324(1988) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties."Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human gene for monoamine oxidase type A."Nucleic Acids Res. 19:4537-4541(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Human monoamine oxidase A and B genes exhibit identical exon-intron organization."Proc. Natl. Acad. Sci. U.S.A. 88:3637-3641(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Promoter organization and activity of human monoamine oxidase (MAO) A and B genes."J. Neurosci. 12:4437-4446(1992) [PubMed] [Europe PMC] [Abstract]
  9. "The promoter of the human monoamine oxidase A gene."Prog. Brain Res. 106:57-66(1995) [PubMed] [Europe PMC] [Abstract]
  10. "A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression."J. Neurochem. 63:843-856(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Partial amino acid sequence analysis of human placenta monoamine oxidase A and bovine liver monoamine oxidase B."Biochem. Biophys. Res. Commun. 156:445-450(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Monoamine oxidase A from human placenta and monoamine oxidase B from bovine liver both have one FAD per subunit."Biochem. J. 260:725-729(1989) [PubMed] [Europe PMC] [Abstract]
  13. "High-level expression of human liver monoamine oxidase A in Pichia pastoris: comparison with the enzyme expressed in Saccharomyces cerevisiae."Protein Expr. Purif. 24:152-162(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines."Mol. Pharmacol. 43:888-893(1993) [PubMed] [Europe PMC] [Abstract]
  15. "Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A."Science 262:578-580(1993) [PubMed] [Europe PMC] [Abstract]
  16. "A functional polymorphism in the monoamine oxidase A gene promoter."Hum. Genet. 103:273-279(1998) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B."Proc. Natl. Acad. Sci. U.S.A. 102:12684-12689(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors."Proc. Natl. Acad. Sci. U.S.A. 105:5739-5744(2008) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  21. "A population-specific HTR2B stop codon predisposes to severe impulsivity."Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract]
  22. "20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition." Eur. J. Hum. Genet. 22:776-783(2014) [PubMed] [Europe PMC] [Abstract]