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Histone Acetyltransferase 1 (HAT1)

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KAT1; Histone acetyltransferase type B catalytic subunit

Histone Acetyltransferase 1 (HAT1)
CCC B952
HGNC 4821
MGI 96013
PubMed 24459728
RGD 1305716
UniProt O14929
Wiki HAT1

Histone acetyltransferases (HAT) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine.

Histone acetyltransferase 1, alsoknown as HAT1, is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB952Hu01 Recombinant Histone Acetyltransferase 1 (HAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB952Hu01 Polyclonal Antibody to Histone Acetyltransferase 1 (HAT1) WB; IHC; ICC; IP.
MAB952Hu22 Monoclonal Antibody to Histone Acetyltransferase 1 (HAT1) WB; IHC; ICC; IP.
Assay Kits SEB952Hu ELISA Kit for Histone Acetyltransferase 1 (HAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB952Mu01 Recombinant Histone Acetyltransferase 1 (HAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB952Mu01 Polyclonal Antibody to Histone Acetyltransferase 1 (HAT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histone Acetyltransferase 1 (HAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Acetyltransferase 1 (HAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB952Ra01 Recombinant Histone Acetyltransferase 1 (HAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB952Ra01 Polyclonal Antibody to Histone Acetyltransferase 1 (HAT1) WB; IHC; ICC; IP.
MAB952Ra21 Monoclonal Antibody to Histone Acetyltransferase 1 (HAT1) WB; IHC; ICC; IP.
Assay Kits SEB952Ra ELISA Kit for Histone Acetyltransferase 1 (HAT1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer."Int. J. Biol. Markers 18:123-129(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Irradiation with heavy-ion particles changes the cellular distribution of human histone acetyltransferase HAT1."Mol. Cell. Biochem. 339:271-284(2010) [PubMed] [Europe PMC] [Abstract]
  8. "The program for processing newly synthesized histones H3.1 and H4."Nat. Struct. Mol. Biol. 17:1343-1351(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1."Proc. Natl. Acad. Sci. U.S.A. 109:8925-8930(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]