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Neurofibromin 2 (NF2)

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ACN; BANF; SCH; Merlin; Bilateral Acoustic Neuroma; Schwannomin; Schwannomerlin; Moesin-Ezrin-Radixin-Like Protein

Neurofibromin 2 (NF2)
CCC B946
HGNC 7773
MGI 97307
PubMed 11809806
RGD 3169
UniProt P35240
Wiki NF2

Merlin is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II.Sequence data reveal its similarity to the ERM protein family.The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein". Human merlin is coded by the gene NF2 in Chromosome 22. Mouse merlin gene is located on the chromosome 11 and rat merlin gene on the chromosome 17. Fruit fly merlin gene (symbol Mer) is located on chromosome 1 and shares 58% similarity to its human homologue. Other merlin-like genes are known from a wide range of animals, and the derivation of merlin is thought to be in early metazoa. Merlin is a member of the ERM family of proteins including ezrin, moesin, and radixin, which are in the protein 4.1 superfamily of proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB946Hu01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB946Hu01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
MAB946Hu22 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
Assay Kits SEB946Hu ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB946Mu01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB946Mu01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neurofibromin 2 (NF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurofibromin 2 (NF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurofibromin 2 (NF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurofibromin 2 (NF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurofibromin 2 (NF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurofibromin 2 (NF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurofibromin 2 (NF2) ELISA Kit Customized Service Offer
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  9. "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins."J. Biol. Chem. 273:1273-1276(1998) [PubMed] [Europe PMC] [Abstract]
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  15. "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation."Oncogene 27:4056-4064(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  19. "Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded."Dev. Cell 18:288-299(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Kibra Is a regulator of the Salvador/Warts/Hippo signaling network."Dev. Cell 18:300-308(2010) [PubMed] [Europe PMC] [Abstract]
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  32. "A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2."Hum. Genet. 97:224-227(1996) [PubMed] [Europe PMC] [Abstract]
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  36. ErratumJ. Med. Genet. 36:87-87(1999)
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  39. "Preimplantation diagnosis for neurofibromatosis."Reprod. BioMed. Online 4:218-222(2002) [PubMed] [Europe PMC] [Abstract]
  40. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
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  42. "Molecular characterization of the NF2 gene in Korean patients with neurofibromatosis type 2: a report of four novel mutations."Korean J. Lab. Med. 30:190-194(2010) [PubMed] [Europe PMC] [Abstract]