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Epiregulin is a secreted peptide hormone that is a member of the EGF family, which includes epidermal growth factor (EGF), transforming growth factor (TGF)-alpha, amphiregulin (ARG), HB (heparin-binding)-EGF, betacellulin, and various heregulins. It is expressed as a type I membrane pro-form, proepiregulin, and then cleaved to a 46 amino acid soluble form by disintegrin and metalloproteinase (ADAM). As a ligand of epidermal growth factor receptor (EGFR) and most members of the ERBB family, epiregulin contributes to inflammation, tissue repair, wound healing, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB945Hu01 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB945Hu02 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB945Hu03 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB945Hu04 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB945Hu01 | Polyclonal Antibody to Epiregulin (EREG) | WB |
| MAB945Hu22 | Monoclonal Antibody to Epiregulin (EREG) | WB; IHC; ICC; IP. | |
| PAB945Hu02 | Polyclonal Antibody to Epiregulin (EREG) | WB | |
| PAB945Hu04 | Polyclonal Antibody to Epiregulin (EREG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB945Hu | ELISA Kit for Epiregulin (EREG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB945Hu | CLIA Kit for Epiregulin (EREG) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB945Mu01 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB945Mu02 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB945Mu01 | Polyclonal Antibody to Epiregulin (EREG) | WB; IHC; ICC; IP. |
| PAB945Mu02 | Polyclonal Antibody to Epiregulin (EREG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB945Mu | ELISA Kit for Epiregulin (EREG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB945Mu | CLIA Kit for Epiregulin (EREG) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB945Ra01 | Recombinant Epiregulin (EREG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB945Ra01 | Polyclonal Antibody to Epiregulin (EREG) | WB; IHC; ICC; IP. |
| MAB945Ra21 | Monoclonal Antibody to Epiregulin (EREG) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB945Ra | ELISA Kit for Epiregulin (EREG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB945Ra | CLIA Kit for Epiregulin (EREG) | Chemiluminescent immunoassay for Antigen Detection. |
- "Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family."Biochem. J. 326:69-75(1997) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4."Oncogene 15:2841-2848(1997) [PubMed] [Europe PMC] [Abstract]
- "Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity."FEBS Lett. 553:232-238(2003) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]