Cluster Of Differentiation 19 (CD19)

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B4; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12

Cluster Of Differentiation 19 (CD19)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. The cytoplasmic tail of CD19 becomes phosphorylated which leads to binding by Src-family kinases and recruitment of PI-3 kinase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB873Hu01 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
EPB873Hu61 Eukaryotic Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
APB873Hu61 Active Cluster Of Differentiation 19 (CD19) Cell culture; Activity Assays.
Antibodies PAB873Hu01 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC
MAB873Hu22 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
LAB873Hu41 PE-Linked Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IF.
MAB873Hu21 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB
MAB873Hu23 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB
MAB873Hu24 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB
MAB873Hu25 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB
Assay Kits SEB873Hu ELISA Kit for Cluster Of Differentiation 19 (CD19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB873Mu01 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB873Mu02 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB873Mu01 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB
PAB873Mu02 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
Assay Kits SEB873Mu ELISA Kit for Cluster Of Differentiation 19 (CD19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB873Ra01 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB873Ra02 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB873Ra01 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB
MAB873Ra21 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; ICC/IF
MAB873Ra22 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) ICC/IF
MAB873Ra23 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) ICC/IF
MAB873Ra24 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) ICC/IF
MAB873Ra25 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; ICC/IF
Assay Kits SEB873Ra ELISA Kit for Cluster Of Differentiation 19 (CD19) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail."J. Exp. Med. 168:1205-1210(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese."Genes Immun. 3:S21-S30(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells."Biochem. Biophys. Res. Commun. 194:222-225(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Tyrosine phosphorylation of CD19 in pre-B and mature B cells."EMBO J. 12:2691-2696(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines."J. Immunol. 164:3123-3131(2000) [PubMed] [Europe PMC] [Abstract]
  12. "An antibody-deficiency syndrome due to mutations in the CD19 gene."N. Engl. J. Med. 354:1901-1912(2006) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]