Cluster Of Differentiation 19 (CD19)

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B4; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12

Cluster Of Differentiation 19 (CD19)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. The cytoplasmic tail of CD19 becomes phosphorylated which leads to binding by Src-family kinases and recruitment of PI-3 kinase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB873Hu01 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
EPB873Hu61 Eukaryotic Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
APB873Hu61 Active Cluster Of Differentiation 19 (CD19) Cell culture; Activity Assays.
Antibodies PAB873Hu01 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Hu22 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
LAB873Hu41 PE-Linked Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IF.
MAB873Hu21 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Hu23 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Hu24 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Hu25 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
Assay Kits SEB873Hu ELISA Kit for Cluster Of Differentiation 19 (CD19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB873Mu01 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB873Mu02 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB873Mu01 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
PAB873Mu02 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
Assay Kits SEB873Mu ELISA Kit for Cluster Of Differentiation 19 (CD19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB873Ra01 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB873Ra02 Recombinant Cluster Of Differentiation 19 (CD19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB873Ra01 Polyclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Ra21 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Ra22 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Ra23 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Ra24 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
MAB873Ra25 Monoclonal Antibody to Cluster Of Differentiation 19 (CD19) WB; IHC; ICC; IP.
Assay Kits SEB873Ra ELISA Kit for Cluster Of Differentiation 19 (CD19) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail."J. Exp. Med. 168:1205-1210(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."J. Immunol. 143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."Mol. Cell. Biol. 12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."Immunogenetics 35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese."Genes Immun. 3:S21-S30(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells."Biochem. Biophys. Res. Commun. 194:222-225(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Tyrosine phosphorylation of CD19 in pre-B and mature B cells."EMBO J. 12:2691-2696(1993) [PubMed] [Europe PMC] [Abstract]
  11. "Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines."J. Immunol. 164:3123-3131(2000) [PubMed] [Europe PMC] [Abstract]
  12. "An antibody-deficiency syndrome due to mutations in the CD19 gene."N. Engl. J. Med. 354:1901-1912(2006) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]