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Receptor Tyrosine Protein Kinase erbB-2 (ErbB2)

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CD340; EGFR2; HER-2/neu; HER2; NEU; MLN 19; NGL; TKR1; p185; Epidermal Growth Factor Receptor 2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2; Neuro/Glioblastoma Derived Oncogene Homolog

Receptor Tyrosine Protein Kinase erbB-2 (ErbB2)
CCC B867
HGNC 3430
MGI 95410
PubMed 24248091
RGD 2561
UniProt P04626

epidermal growth factor receptor 2  is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB867Hu01 Recombinant Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB867Hu02 Recombinant Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Positive Control; Immunogen; SDS-PAGE; WB.
APB867Hu01 Active Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Cell culture; Activity Assays.
APB867Hu02 Active Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Cell culture; Activity Assays.
Antibodies PAB867Hu01 Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
MAB867Hu22 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
LAB867Hu81 FITC-Linked Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IF.
LAB867Hu71 Biotin-Linked Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC.
PAB867Hu02 Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
MAB867Hu21 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
MAB867Hu23 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
MAB867Hu24 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
MAB867Hu27 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
MAB867Hu29 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
Assay Kits SEB867Hu ELISA Kit for Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB867Mu01 Recombinant Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB867Mu02 Recombinant Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB867Mu01 Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
PAB867Mu02 Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
Assay Kits SEB867Mu ELISA Kit for Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB867Ra01 Recombinant Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB867Ra01 Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
LAB867Ra81 FITC-Linked Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IF.
LAB867Ra71 Biotin-Linked Polyclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC.
MAB867Ra21 Monoclonal Antibody to Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) WB; IHC; ICC; IP.
Assay Kits SEB867Ra ELISA Kit for Receptor Tyrosine Protein Kinase erbB-2 (ErbB2) Enzyme-linked immunosorbent assay for Antigen Detection.
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