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Paxillin (PXN)

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Pax

Paxillin (PXN)
CCC B844
HGNC 9718
MGI 108295
PubMed 11146675
UniProt P49023
Wiki Paxillin

Paxillin is a signal transduction adaptor protein and should not be confused with the neurotoxin paxilline.Glenney and Zokas (1989) used an antiphosphotyrosine antibody to identify proteins that are phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts, and found a 76-kD protein that localizes to focal adhesions at the ends of actin-containing stress fibers in nontransformed cells. Turner et al. (1990) purified this protein from chicken gizzard smooth muscle, and named it paxillin ('paxillus' means 'small stake' or 'peg' in Latin) as a protein tethered to the membrane at focal adhesions.Paxillin migrates as a diffuse 65- to 70-kD band on SDS-PAGE. Salgia et al. (1995) stated that transmembrane integrin molecules connect the actin cytoskeleton to the extracellular matrix within focal adhesions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB844Hu01 Recombinant Paxillin (PXN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB844Hu01 Polyclonal Antibody to Paxillin (PXN) WB; IHC; ICC; IP.
MAB844Hu22 Monoclonal Antibody to Paxillin (PXN) WB; IHC; ICC; IP.
Assay Kits SEB844Hu ELISA Kit for Paxillin (PXN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB844Mu01 Recombinant Paxillin (PXN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB844Mu01 Polyclonal Antibody to Paxillin (PXN) WB; IHC; ICC; IP.
Assay Kits SEB844Mu ELISA Kit for Paxillin (PXN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB844Ra01 Recombinant Paxillin (PXN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB844Ra01 Polyclonal Antibody to Paxillin (PXN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Paxillin (PXN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paxillin (PXN) ELISA Kit Customized Service Offer
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  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity."J. Biol. Chem. 285:24099-24107(2010) [PubMed] [Europe PMC] [Abstract]
  24. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
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  28. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  29. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain."Structure 11:1207-1217(2003) [PubMed] [Europe PMC] [Abstract]
  31. "Paxillin and ponsin interact in nascent costameres of muscle cells."J. Mol. Biol. 369:665-682(2007) [PubMed] [Europe PMC] [Abstract]
  32. "The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly."J. Biol. Chem. 283:21113-21119(2008) [PubMed] [Europe PMC] [Abstract]
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  35. "Structural basis for paxillin binding and focal adhesion targeting of beta-parvin."J. Biol. Chem. 287:32566-32577(2012) [PubMed] [Europe PMC] [Abstract]