≡

Complement Factor D (CFD)

[Edit]

CF-D; DF; PFD; ADN; Adipsin; Properdin Factor D; C3 convertase activator

Complement Factor D (CFD)
CCC B833
HGNC 2771
MGI 87931
PubMed 1374388
RGD 2498
UniProt P00746
Wiki Factor_D
Factor D isa member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.
Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB833Hu01 Recombinant Complement Factor D (CFD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB833Hu02 Recombinant Complement Factor D (CFD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB833Hu01 Polyclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
MAB833Hu22 Monoclonal Antibody to Complement Factor D (CFD) WB; IHC
MAB833Hu21 Monoclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
MAB833Hu23 Monoclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
Assay Kits SEB833Hu ELISA Kit for Complement Factor D (CFD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB833Mu01 Recombinant Complement Factor D (CFD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB833Mu02 Recombinant Complement Factor D (CFD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB833Mu01 Polyclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
PAB833Mu02 Polyclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
LAB833Mu81 FITC-Linked Polyclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IF.
Assay Kits SEB833Mu ELISA Kit for Complement Factor D (CFD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB833Ra01 Recombinant Complement Factor D (CFD) Positive Control; Immunogen; SDS-PAGE; WB.
APB833Ra01 Active Complement Factor D (CFD) Cell culture; Activity Assays.
Antibodies PAB833Ra01 Polyclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
MAB833Ra21 Monoclonal Antibody to Complement Factor D (CFD) WB; IHC; ICC; IP.
Assay Kits SEB833Ra ELISA Kit for Complement Factor D (CFD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue."J. Biol. Chem. 267:9210-9213(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Amino acid sequence of human D of the alternative complement pathway."Biochemistry 23:2482-2486(1984) [PubMed] [Europe PMC] [Abstract]
  5. "Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin."FEBS Lett. 166:347-351(1984) [PubMed] [Europe PMC] [Abstract]
  6. "Partial amino acid sequence of human factor D: homology with serine proteases."Proc. Natl. Acad. Sci. U.S.A. 77:1116-1119(1980) [PubMed] [Europe PMC] [Abstract]
  7. "Active site amino acid sequence of human factor D."Proc. Natl. Acad. Sci. U.S.A. 77:4938-4942(1980) [PubMed] [Europe PMC] [Abstract]
  8. "Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site."Biochem. J. 187:863-874(1980) [PubMed] [Europe PMC] [Abstract]
  9. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of human factor D. A complement system protein at 2.0-A resolution."J. Mol. Biol. 235:695-708(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of a complement factor D mutant expressing enhanced catalytic activity."J. Biol. Chem. 270:24399-24405(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections."Blood 107:4865-4870(2006) [PubMed] [Europe PMC] [Abstract]