V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB)

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REL-B; I-REL; Transcription Factor RelB; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3

V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB)
Bours et al. (1994) demonstrated that human RELB, when generated in mammalian cells, formed kappa-B-binding heterodimeric complexes with p50 (NFKB1) or p52 (NFKB2). Homodimeric complexes of RELB did not show DNA-binding activity.NF-kappa-B-inducing kinase (NIK, or MAP3K14) is required for osteoclastogenesis in response to pathologic stimuli. Vaira et al. (2008) found that overexpression of Relb, but not Rela, rescued differentiation of mouse Nik -/- osteoclast precursors, indicating that blockade of the alternative NF-kappa-B pathway, rather than the classical NF-kappa-B pathway, is responsible for the osteoclastogenic defect in the absence of Nik. Using Relb -/- mice, they showed that Relb itself was required for Rankl-induced osteoclastogenesis in vitro and for TNF-induced bone resorption in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB826Hu01 Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB826Hu01 Polyclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) WB
MAB826Hu22 Monoclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) WB; IHC; ICC; IP.
Assay Kits SEB826Hu ELISA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB826Mu01 Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB826Mu01 Polyclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) WB; IHC; ICC; IP.
Assay Kits SEB826Mu ELISA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) Enzyme-linked immunosorbent assay for Antigen Detection.
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